Please note that the lengths of the cell-cycle stages are not drawn to scale. APC/C (Anaphase-promoting complex/cyclosome). A ubiquitin ligase which, together with a ubiquitin-conjugating enzyme, attaches ubiquitin peptides to a substrate protein. Ubiquitylated proteins are recognized by the 26S...
Abnormal chromosome behavior at subsequent meiotic stages was rare in these cases. With heterozygosity for the third inversion, however, homologous synapsis was generally found in the distal regions of the chromosome involved, the inverted region was often non-homologously synapsed, and a substantial ...
Although it is not clear where this activation occurred, it can be anticipated that cells at the early stages of meiosis where recombi- national DSBs repair occurs could have the ability to engage their already active recombination machinery in elongating their own eroded telomeres. Lusting and ...
These stages are conveniently defined by the status of the synaptonemal complex (SC), a highly conserved structure that connects the axes of homologs, along their entire lengths, at a distance of ∼100 nm via a close-packed array of transverse filaments (e.g., Figure 1D). DSBs occur ...
Note protein divergence between the two groups of genes at late time points (represented by gray box), suggesting synthesis co-regulation for all but independent post-translational adjustment for two complexes at late stages. See also Figure 4. Analysis of proteasome components similarly revealed a ...
We suggest that PRDM9 acts as a physical barrier to MRE11 activity, preventing SPO11 release during the early stages of homolog engagement. This generates a PRDM9-dependent SPO11-bound recombination intermediate (SPO11-RI). We propose that SPO11-RI may favor high-fidelity homologous ...