Crossing over is essential in increasing genetic variation. Metaphase I –Chromosomes line up at the equator of the cell, where the sequence of the chromosomes lined up is at random, through chance, increasing genetic variation via independent assortment. Anaphase I –The homologous chromosomes move...
“Chromosome structure and the mechanism of crossing-over.”J. Arnold Arbor.11, 193–220. Google Scholar —— (1932). “Meiosis and chiasma formation inPaeonia suffruticosa.” Ibid.13, 375–84. Google Scholar —— (1934). “Interlocking as a ‘demonstration’ of the occurrence of ...
This requirement can be explained by the failure of Sgo1 to localize to kineto- chores in the bub1∆ mutant84. In budding yeast, two kinetochore proteins, increased minichromosome loss (Iml)3 and chromosome loss (Chl)4, are required for the maintenance of centromeric cohesion in meiosis I ...
This could be explained by the fact that, when neither the MTs nor the KCs are diffusing, the MTs have to reach for the fixed KCs just by growing. Time is lost when a MT is not growing directly towards a KC, so the search and capture mechanism alone is the slowest search strategy. ...
In meiotic cells, this discrepancy is easily explained since the activity of Yen1 is negatively regulated by CDK1-dependent phosphorylation, preventing the activation of the nuclease during prophase I [9]. Elimination of CDK-phosphorylation sites in Yen1 prematurely turns on its enzymatic activity ...