delivering proteins and microRNAs into target cells to mediate therapeutic effects. Neuroprotection, achieved through receptor-mediated activation of JAK, STAT3, RAF, MEK, ERK, and SMAD pathways, promoting cell survival and reducing
this attribute is unable to counteract tubular damage in the CKD fibrotic microenvironment. CKD includes a heterogenous spectrum of clinical conditions. Nevertheless, CKD pathogenesis shares the characteristic of escalating fibrosis, often initiating with a primary injury (cell loss or abnormal behavior) l...
Clinical trials based on MSCs therapy in IBD conditions registered onhttps://clinicaltrials.gov(June 2022). The schematic exhibits the clinical studies in the light of cell source (A), cell type (B), administration route (C), condition (D), study phase (E), and study location (F). Inf...
Stem cells derived from the bone marrow are factories that secrete many growth factors and other molecules than have major effects on multiple pathways (FIG. 1) [T. Kinnaird, E. Stabile, M. S. Burnett, C. W. Lee, S. Barr, S. Fuchs, S. E. Epstein. Marrow-Derived Stromal Cells Expr...
The therapeutic potential and safety of MSCs have been extensively studied and numerous clinical trials are published Stem Cells International 5 with additional ones under trail. Moreover, the therapeutic potential of MSCs may be attributable to the paracrine factors contained in MVs. M...