as well as in other cells, MCFAs are as rapidly oxidized as glucose; they do not require the enzyme carnitine palmitoyltransferase for their intramitochondrial transport, they easily cross their membranes, and within these, they are activated by the enzyme medium-chain acyl-CoA synthetase (Venugop...
We have also used [1- 14 C]3-OH C20:0-CoA to investigate the reductant requirement of the enoyl-CoA reductase of the acyl-CoA elongase complex. In the presence of NADPH, [1- 14 C]3-OH C20:0-CoA conversion was stimulated. Aside from the product of dehydration...
Eukaryotes express a multi-component fatty acid elongase to produce very long chain fatty acids (VLCFAs), which are building blocks of diverse lipids. Elongation is achieved by cyclical iteration of four reactions, the first of which generates a new carbon鈥揷arbon bond, elongating the acyl-...
Very long chain fatty acids (VLCFAs) are essential building blocks for the synthesis of ceramides and sphingolipids. The first step in the fatty acid elongation cycle is catalyzed by the 3-keto acyl-coenzyme A (CoA) synthases (in mammals, ELOVL elongases). Although ELOVLs are implicated in...