Institutional affiliations: Authors should use either the full, standard title of their institution or the standard abbreviation of the institutional name so that the institutional name can be independently verified for research integrity purposes. Studies in humans and animals Authors must follow ethical...
Abbreviation: BICR, blinded independent central review; PR, partial response; SD, stable disease; PD, progressive disease; FAS, full analysis set; RECIST: Response Evaluation Criteria in Solid Tumors Full size image Fig. 4 A Kaplan–Meier curve for BICR-assessed PFS and investigator-assessed PFS...
Abbreviation: Q1: the 1st quartile; Q3: the 3rd quartile; IQR: the interquartile range; * P < 0.05, ** P < 0.01, *** P < 0.001; ns. not significant. Extended Data Table 1 Characteristics of the IMAGEN cohort at age 14 Full size table Extended Data Table. 2 ...
intracellular drug accumulation in resting cells decreases, leading to chemotherapy drug resistance [96,97]. Itamochi et al. found that OCCC had a longer doubling time compared to high-grade serous ovarian carcinoma (HGSOC) (61.4 h vs. 29.8 h) [98] and when chemoresistant cells were derived...
Abbreviation: CSR, clinical study report. Figure 2. Random Effects Meta-Analysis on the Outcome of Hospitalization Within the ITTi Population Aged 12 Years and Older View LargeDownload “Yes” indicates the number of individuals hospitalized, and “No” indicates the number of individuals who were ...
(Weak) across the annotator models, and are shown in Fig.3c. The average pairwise Cohen’s κ score is 0.255 (Minimal agreement). Fleiss’ κ for these predicted labels is 0.236 (Fair agreement). Note, IAA is used as an abbreviation for “Inter-Annotator Agreement” throughout this paper...
Abbreviation:RCT, randomized controlled trial. Data fromRefs.29,33,52,53 RITZ-1 tested whether a 24-hour infusion of 25 mg/h of tezosentan improved patients’ self-assessed dyspnea at 24 hours after the start of infusion. No significant improvement in dyspnea was seen in 669 patients hospi...
As computer technology has developed, in silico approaches such as virtual screening and network analysis have been widely utilized in efforts to elucidate the pharmacological basis of the functions of traditional medicinal plants. In the process of new drug discovery, the application of virtual ...
Table 1. Delays in regulatory approval before the initiation of clinical trials Management of clinical study Challenges Regulatory qualification Clinical site selection Clinical protocol Trial insurance Abbreviation: EU= European Union. Specific challenges Interventional France, Serbia Non-interventional The ...
UniProt ID numbers are provided in parentheses. TABLE 1 AD Diagnosis Biomarkers Biomarker Name (UniProt ID) Abbreviation(s) References Angiotensin converting enzyme ACE, CD143 Zou et al., Helbecque et al., (P12821) Wright and Harding Alpha 1 antitrypsin (Q86U18) Song et al. Apolipoprotein ...