A lentivirus-based treatment restores immune function with minimal side effects in children with adenosine deaminase deficiency. Karen O’Leary News & Views|01 February 2021 A plethora of gene therapies for hemoglobinopathies CRISPR-Cas gene editing enters the field of promising clinical approaches for...
Substances : Vitamin E Diseases : Cardiovascular Disease: Prevention, Cardiovascular Diseases, Vitamin E Deficiency Pharmacological Actions : Cardioprotective Additional Keywords : Risk Factors [+] A high level of vitamin E might be a protective factor for populations at risk for pancreatic cancer.Dec...
Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing of drugs that target the transcription factor HIF or HIF-responsive growth factors, such as VEGF, for the treatment of cancers caused by VHL inactivation, such as
Ross AC. Dietary reference intakes for calcium and vitamin D. National Academies Press; 2011. Google Scholar Rucker RB, Lanoue L. Trace minerals: metabolism and deficiency (copper, zinc, selenium, manganese). In: Encyclopedia of gastroenterology; 2004. p. 502–7. https://doi.org/10.1016/b0...
The recommended daily vitamin D intake reaches 400 IU for infants up to 1 year of age; while in children/adolescents from 1 to 18 years – 600 IU. Of note, supplementation is crucial for infants, as even 8 weeks-old infant may develop vitamin D deficiency. Similarly, recommended daily ...
Gender medicine is not new in pediatric and neonatal care. In 1971, Naeye et al. introduced the “hypothesis of the male disadvantage”, which describes the increased perinatal mortality in males compared with females [6]. In 2004, among the US population, the mortality rate for female infant...
Gender medicine is not new in pediatric and neonatal care. In 1971, Naeye et al. introduced the “hypothesis of the male disadvantage”, which describes the increased perinatal mortality in males compared with females [6]. In 2004, among the US population, the mortality rate for female infant...
【13】Long-term and real-world safety and efficacy of retroviral gene therapy for adenosine deaminase deficiency(腺苷脱氨酶缺乏症的逆转录病毒基因治疗的长期和现实世界安全性和有效性):该研究对43名患有腺苷脱氨酶缺乏症的患者进行了15年的随访,结果显示逆转录病毒基因治疗在长期有效性方面表现良好,需要继续对...
be highly heterogeneous, from a slowly progressive syndrome punctuated by periods of good health [15], to subacute, rapidly progressive, and fatal neurological deficits in adulthood, as in the case of TTC19 mutations [16], to different phenotypes as for Thymidine kinase 2 deficiency syndrome [17...
Biomarker-directed targeted therapy plus durvalumab in advanced non-small-cell lung cancer: a phase 2 umbrella trial Long-term and real-world safety and efficacy of retroviral gene therapy for adenosine deaminase deficiency RANKL blockade for erosive hand osteoarthritis: a randomized placebo-controlled ...