Genetically adjusted PSA levels for prostate cancer screening Analyses of large population-based cohorts and clinical trials show that using polygenic scores to account for variability in PSA levels improves detection of prostate cancer, suggesting an approach for enhancing screening accuracy. Linda Kach...
High levels of sensitivity (89.5%) and specificity (90%) were reported, but Young and colleagues considered the true level of accuracy was likely to be lower given few patients with a normal PSA level had the reference test for prostate cancer. Strengths and weaknesses This study benefited ...
Indeed, serum PSA levels are increased in patients with benign prostatic diseases such as benign prostatic hypertrophy and prosta- titis. Recently, new prostate cancer antigens have been reported and examined as target antigens for cancer-spe- cific immunotherapy [21-23]. In the present study, ...
68Ga-PSMA PET/CT has become the gold standard in the diagnosis of biochemical recurrence and provides a high probability of localizing recurrence even at very low PSA levels starting at 0.2 ng/ml, thus, enabling appropriate therapy. Therapy with 177Lu-PSMA has been shown to be effective ...
Capsaicin sidelined NF-kB in Koeffler's tests. Capsaicin was also linked to lower levels of prostate specific antigen (PSA); high blood levels of PSA may signal prostate cancer. Cancer is complicated, involving more chemicals than just NF-kB. However, Koeffler's team says capsaicin is tolerab...
These tumors were relatively less prevalent in real-world populations and often could be of challenge for conventional gastroscopy to detect at early stages. Nonetheless, our cfDNA-based assay achieved high sensitivity regardless of tumor locations. Of note, in all three cohorts, all gastric tumors ...
S4A-C. Of note, SAFB is an AR co-regulator, and loss of SAFB increased AR and PSA levels [36]. These findings suggest that SAFB drives a more aggressive phenotype in PC in Black men. GTF2B might also be the potential AR repressor gene in Black PC patients; however, this requires ...
Currently, the selection of patients for AS is based on a combination of digital rectal examination (DRE) results, prostate-specific antigen (PSA) levels, Gleason score from prostate biopsies, and the rate of tumor-positive biopsy cores. Some protocols also incorporate PSA density, the rate of ...
Timeline markers for the emergence of the first evolutionary clone and the dominant clone detected in the metastasis are noted as “1st met” and “adv. met”. On the right to the cladogram, plasma total prostate specific antigen (PSA) levels are placed on the timeline in dark gray, ...
This explanation is supported by local proteomics analyses of different tumors, which all show high AUCs, greater than 0.9. Thus, multi-omics biomarkers for the diagnosis of individual cancers may potentially be effective, but not for groups of cancers....