Finally, cell supernatant was collected and used to measure nitric-oxide (NO) levels by Griess reagent. Results and conclusion: LWB was non cytotoxic up to 2 mg/ml. The MIC of LWB to inhibit SA was 5 mg/ml while LWB was unable to inhibit CK even in 10 mg/ml. However, 2 mg/ml ...
Solasonine (SS), a glycoalkaloid fromSolanum nigrum L,demonstrates potential in cancer therapy, showing antitumor effects on lung cancer cells. Its action involves inducing ferroptosis, marked by increased levels of LPO, iron, and ROS. The effectiveness of SS is attributed to compromised antioxidant...
if not totally, will-independent, while it is, at the same time, strictly age- and lifestyle-dependent [6,7]. Incorrect behavioral choices are in fact able to affect the ability both to obtain and to maintain an erection
Methylation-specific qPCR & bisulfite conversion Rhesus-specific primers and probes were designed for CACNA1G, CDKN2A, CRABP1, MLH1, and NEUROG1, CIMP markers used in humans [16]. We queried the region -1.500 bp to + 500 bp of the gene start (Mmul_10 [23]) utilizing IGV [28],...
To explore whether the TXNIP loss-induced suppression of proliferation in RPE cells results from an interplay between autophagy and proliferation, we first evaluated the effects of oxidative stress on the induction of autophagy in ARPE-19 cells. The conversion of microtubule-associated protein 1 A...
Bergamot extract (0.85 and 0.56 mg/ml) was reported to reduce the cholesterol content, lipid droplet accumulation and reactive oxygen species levels in murine pre-adipocytes 3T3-L1 cells [60]. The lipid-lowering mechanism is related to the inhibition of hydroxymethyl glutaryl-CoA reductase (HMGCR)...
Hypertension, which directly threatens quality of life, is a major contributor to cardiovascular and cerebrovascular events. Over the past two decades, domestic and foreign scholars have agreed upon various standards in the treatment of hypertension, and considerable progress has been made in the field...
Percy Medicine is a nonprescription gastrointestinal suspension containing bismuth subsalicylate as the active ingredient (1050 mg/10-ml dose). A 3-month-old infant with colic developed salicylate toxicity requiring hospitalization in the pediatric intensive care unit (PICU) as a result of continued ...
3.2 mL/kg, i.g. 16 w plasma: SOD↑ and GPX↑; serum: NO↓, VEGF↓ and ICAM-1↓; retina: thickness of INL↑; swelling of GCL↓; protein of VEGF↓ and iNOS↓; mRNA of ICAM-1↓ [84] MFD SD 8−10 w 200−250 high-fat diet 2 w; 55 mg/kg STZ, once i.p....
The stock solution of etoposide-d3 (IS) was prepared by dissolving 1.00 mg powder in 1.00 mL of methanol to a 1.00 mg/mL concentration. The working solution of IS was prepared by a 1/10 dilution of the stock solution in methanol to a concentration of 0.100 mg/mL (169 µM). Two ...