Background: There are increasing reports of propylene glycol (PG) toxicity, which is used in many medications as a solvent for water-insoluble drugs. Polypharmacy may increase PG exposure in vulnerable PICU patients who may accumulate PG due to compromised liver and renal function. The study aim...
Ryfadin (Rifampin, Rimactene): used for avian TB; inhibits the growth of the tuberculosis organism and enhances the effectiveness of Isoniazid, with which it is combined; given orally; has numberous drug interactions; side effects are numerous and associated with most body systems; hepatoxic; do...
The propylene glycol is used as vehicle in the Hydropast; the vehicle used in the Hydropast is classified as a viscous vehicle with high molecular weight and, as well as polyethylene glycol 400, prolong the action of calcium hydroxide in the root canal system [26]. Moreover, propylene glyco...
The midazolam intranasal formulation includes several organic solvents including ethanol, PEG-6 methyl ether, polyethylene glycol 400, and propylene glycol.21 The diazepam nasal spray formulation includes dodecyl maltoside (Intravail® A3; 0.25% w/v), an alkylsaccharide, and vitamin E.10,22,38 ...
(available outside the United States), propylene glycol-urea-lactic acid, ketoconazole (Nizoral cream, Xolegel), such as terbinafine (Lamisil cream), tavaborole 5% solution (Kerydin), toliaftate (Tinactin), naftifine (Naftin), butenafine (Lotrimin), griseofulvin (Gris-PEG), ciclopirox (Ciclo...
The preparations described herein contain and may additionally contain and be freely exchangeable with any pharmaceutically acceptable excipient or additive, such as for example, dextrose, polyethylene glycol (PEG), hydroxypropyl methylcellulose (HPMC), sodium chloride, potassium chloride, calcium chloride,...
Other suitable carriers comprise water-in-oil or oil-in-water emulsions and mixtures of emulsifiers and emollients with solvents such as sucrose stearate, sucrose cocoate, sucrose distearate, mineral oil, propylene glycol, 2-ethyl-1,3-hexanediol, polyoxypropylene-15-stearyl ether and water. For ...
There is an increasing number of reports of propylene glycol (PG) toxicity in the literature, regardless of its inclusion on the Generally Recognized as Safe List (GRAS).1 PG is an excipient used in many medications as a solvent for water-insoluble drugs. Polypharmacy may increase PG exposure...
Neonate patient demographic data and information on all medicines prescribed and administered during hospitalization on 1 day between November 2019 and March 2021 were extracted from the medical records. Nine PHEs, paraben, polysorbate 80, propylene glycol, benzoates, saccharin sodium, sorbitol, ethanol...
Interestingly, large quantities of prilocaine could be deposited within the horse joints with minimal synovitis when SAPLs are incorporated within propylene glycol (PG), a polymer commonly used in oral, topical, intravenous, and intramuscular formulations [136]. In addition to this, it is well ...