1, about half of the epilepsy therapy programs are in the clinical phase of development. Overall, 74% of the novel epilepsy therapies are small molecules, while 26% are biologics, i.e., gene therapies, antisense oligonucleotides (ASOs), or RNA-based therapies, antibodies, and proteins or ...
(HealthDay)—A host of new medications that appear to prevent migraine headaches are in the final stages of testing and approval in the United States, according to a presentation at the annual meeting of the American Headache Society, held from June 8 to 11 in Boston. The new injectable dru...
NGR-hTNF: It’s currently in phase III trials to test its use in managing recurring mesothelioma. Preliminary data offers hope the drug can become an effective second-line therapy. Onconase: This drug is toxic to cancer cells. It showed promise during a phase III trial but failed to impro...
“In terms of risk profile testing, drugs are most often tested on one or a few human cell models that mostly come from donors of Northern European descent,” said Zaaijer. “Drugs are then tested in a rodent model. If these tests are successful, drug companies push the drug through to ...
of the testing is done after a few months on samples of the batch that have been retained. If a batch fails stability testing it has to be recalled and destroyed. Manufacturers obviously do not like to lose money like this but then again, they should perhaps invest in quality manufacturing...
In addition to the approved LDL-C, HDL-C, and TG-modifying therapies, several agents are in various development and testing stages, and many are now emerging for potential clinical use. Inclisiran is a small interfering RNA that inhibits hepatic translation of PCSK9 protein. In a pooled ana...
Mayne Pharma as we continue our transition phase and simplify our business. The first quarter of FY24 reflects the hard work undertaken to improve operating performance and drive revenue and margin. Our team are engaged to deliver on the potential of our portfolio in the markets we operate in....
This study protocol outlines the development and pilot testing of a decision aid for antipsychotic medications that is tailored to the information needs of residents with dementia in long-term care and family caregivers (or decision makers). The goals of the decision aid are to help residents and...
During a Case-Based Roundtable® event, Stephanie L. Elkins, MD, discussed with participants how they manage toxicity of transplant-eligible newly diagnosed multiple myeloma in the first article of a 2-part series.
As a result, blood vessels enlarge (dilate), and blood pressure is reduced. Reduced blood pressure makes it easier for the heart to pump blood and can improve heart failure. In addition, the progression of kidney disease due to high blood pressure or diabetes is slowed. ARBs have effects ...