DPA destroys the enzyme that breaks down/inhibits endorphins and in essence raises endorphin levels. Endorphins are feel-good chemicals that you experience with an endorphin rush when you go for a run or when someone gives you a big hug, when you show kindness to someone or an individual does...
Medication overuse headache (MOH) is a secondary headache disorder that leads to pronounced disability and decreased quality of life. Available therapeutic options for MOH are limited, and many are only effective in a subset of individuals. Although the existing evidence is limited, acupuncture may ...
Moreover, it may be possible to consider ferrocifen as a prodrug: the corresponding QM inhibits cytosolic and mitochondrial TrxR more efficiently than the parent compound. However, in order to further analyze the efficacy of these molecules and to perform in vivo studies, ferrocifens need to ...