Levels of olanzapine and clozapine, metabolized via the CYP1A2 pathway, may be decreased by cigarette smoking.71 Clinicians may notice a slightly decreased drug effect when patients are transitioned from a nonsmoking hospital unit to the outpatient setting. • Classifying antipsychotics into 2 distin...
Conclusion: Although general symptom improvement was similar, olanzapine significantly improved insight and presented less medication discontinuation compared to other SGAs, which might partially explain why patients on olanzapine stayed longer on their medications.doi:10.11919/j.issn.1002-0829.217087Hongbo HE...
Sometimes, depression is resistant to treatment with antidepressant medications and may require the use of other medications to effectively manage the symptoms. This might include the use of mood stabilizers, antipsychotics such asrisperidoneandolanzapine, or stimulants such as methylphenidate[3][4]. It...
Sex differences in clinical response to olanzapine compared with haloperidol. Psychiatry Res. 2002; 110(1):27–37. 44. Putting gender on the agenda. Nature. 2010;465(7299):665. 45. Walden R. Gender bias in research. J R Soc Med. 2007;100(2):66. 46. Holdcroft A. Gender bias in ...
For most other outcomes wide confidence intervals were obtained, which meant that it was impossible to judge whether the two compounds were equally effective, or whether one was in fact superior to the other. Olanzapine and risperidone seem broadly similar according to numbers of patients responding...
The proportion of treatment episodes that were at least 1-year long (conceptually similar to 1-year completer rates in RCTs) was 73.7% for clozapine, 57.6% for olanzapine, 52.0% for risperidone, 46.1% for quetiapine, 28.0% for ziprasidone, 30.9% for typicals of high-potency level, 43.6% ...
Concerns regarding increased risk of cerebrovascular events in elderly patients with dementia associated with certain AAPs began in the 2000s,16-19 leading to FDA warnings for risperidone in 2003, olanzapine in 2004, and aripiprazole in 2005.16 A subsequent meta-analysis16 of clinical trials suggest...
Leucht SPitschel-Walz GAbraham DKissling W Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo: a meta-analysis of randomized controlled trials. Schizophr Res 1999;3551- 68PubMedGoogle ...
Antipsychotics: although SGA’s are not mood stabilizers in the strict sense, several SGA’s have been recommended for maintenance treatment in bipolar disorder as monotherapy or combined with a mood stabilizer: quetiapine, asenapine, aripiprazole, olanzapine, risperidone, paliperidone, and lurasidone [...
mostly remitted patients with psychotic depression showed that, compared to patients on placebo, those given olanzapine had decreased cortical thickness within both hemispheres [18]. Other work suggests that antipsychotic medication, particularly second-generation antipsychotics, may exert a neuroprotective ...