This review gives an extensive overview of the non-clinical methods (in vitro, in vivo and in silico) to study the transfer of maternal medication into the human breast milk, and subsequent neonatal systemic exposure. Several in vitro models are available, but model characterization, including ...
Hypertension in PregnancyBeardmore KS, Morris JM, Gallery ED. Excretion of antihypertensive medication into human breast milk: a systematic review. Hypertens Pregnancy. 2002;21: 85-95.Beardmore KS, Morris JM, Gallery ED. Excretion of antihypertensive medication into human breast milk: a systematic ...
It is well recognised that although nutritionally breast milk is the optimal food for babies, there are a number of caveats to this, based on the consequences of the modern lifestyle. Here we have considered ways in which the young breast fed child may be exposed to various environmental and...
The immunomodulators 6-MP and azathioprine have been found in very minute amounts in breast milk, with concentrations highest in the first milk of the day. The current recommendation is for consumption of thiopurines at night with a "pump and dump" strategy for the first milk of the day. ...
that attacks the body’s immune system and damages it. If HIV is not treated in time, it can further lead to AIDS (Acquired Immunodeficiency Syndrome), a more severe condition. HIV is transmitted through bodily fluids, such as; blood, semen, rectal and vaginal fluid, and breast milk. ...
It is important to consider the various properties of a drug when evaluating its possible effects in the breastfeeding infant. In addition, the volume of milk the infant receives and its composition can influence exposure levels. Other factors of importance include the infant's age, frequency of...
Early feeding of the newborn with breast milk or formula is encouraged. For those unable to drink, a nasogastric tube can be used. For those who cannot protect their airway or are unable to drink, nasogastric, intramuscular, intraosseous, or IV routes can be employed for the following drugs...
TYSABRI may cause low platelets, and in some cases also low red blood cells (anemia), in your newborn baby if you take TYSABRI while you are pregnant. It is not known if TYSABRI can cause birth defects. • are breastfeeding or plan to breastfeed. TYSABRI can pass into your breast ...
Most antidepressants can be used safely in breastfeeding. Transient adverse effects such as colic or drowsiness have been reported, however longitudinal studies have not identified any neurodevelopmental concerns.9Sertraline is associated with the lowest excretion in breast milk and is often the medicatio...
The advisability of continuing breastfeeding is an important issue for women with postpartum depression or psychosis. A review of the literature on psychotropic drugs in breast milk is presented. All of the major classes of psychotropic drugs (antidepressants, antipsychotics, antianxiety agents, lithium...