The Penn investigators defined and tracked T-cell responses in mice infected with either an acute or chronic strain of mouse norovirus to gain insight into mechanisms of viral clearance and persistence. At first, they hypothesized that persistentnorovirus infectioncaused T cells to become exhausted ren...
This was reflected by reduced lethality, faster clearance of productive infection, a reduced viral genome load in organs of survivors during latency, and a reduced risk of reactivation upon secondary immune cell depletion. Adoptive CD4+ T cell transfer failed to protect and infection of HCT ...