LiteBus is an easy-to-use and ambitious in-process mediator providing the foundation to implement Command Query Separation (CQS). It is implemented with minimal reflection and instead utilizes covariance and contravariance to provide its core functionali
CRISPR-based transcriptional activation is a powerful tool for functional gene interrogation; however, delivery difficulties have limited its applications in vivo. Here, we created a mouse model expressing all components of the CRISPR-Cas9 guide RNA-directed Synergistic Activation Mediator (SAM) from a...
Currently, the AD research community is facing many different challenges in elucidating the potential functions of gene variants and environmental stressors in the initiation and propagation of AD. Our data provide a confluence of evidence from cellular model, animal model, live human, and postmortem...
This suggests that there is a suppression effect (Watson et al., 2013) and an inconsistent mediation model (O’Rourke & MacKinnon, 2018). In other words, while direct parental involvement is positively associated with parental self-efficacy, which in turn is associated with higher parental QOL,...
methylation-mediated model, the absolute value of the observed G:Y relationship strength reduces toward zero when adjusting for methylation. DMR: differentially methylated region, SNP: single nucleotide polymorphism, CIT: causal inference test. The full list of SNP-DMR pairs is shown in Supplementary...
(2) Policies related to the obligation to contribute foreign investment to infrastructure development projects need to continue to be implemented as long as the human resource level is not able yet to meet the international worker standards so that regencies/cities can continue to enjoy these ...
Process Model 4 (Hayes, 2018) was used to determine whether or not each of the five facets of mindfulness significantly mediated the relationship between ACEs and depression. Mediation analyses were run on the full 279 participants. Analyses revealed that the describe, aware, and non-judgement fac...
For the correlation between endoglin and eGFR, a univariate regression model was used. For the correlation between the endoglin-positive interstitial area and the Sirius Red-positive interstitial area a univariate regression model was used, whereby eGFR was also implemented in the model to correct ...
This participation in enumeration is part of their model of building collective agency and evidence to support their claims. 3.1.2. The Policy Context in SL Sierra Leone signed the UN CRPD on the first day allowable (30 March 2007) and followed with the enactment of the Disability Act in ...