3. Gulmez Karaca K, Brito DVC, Oliveira AMM. MeCP2: A Critical Regulator of Chromatin in Neurodevelopment and Adult Brain Function. Int J Mol Sci. 2019 Sep 16;20(18):4577. doi: 10.3390/ijms20184577. PMID: 31527487; PMCID: PMC6769791....
MeCP2Mouse modelsRett syndromeSynapseMethyl-CpG binding protein 2 (MeCP2) is a member of the methyl-CpG binding domain family of nuclear proteins with binding affinity for methylated deoxyribonucleic acid. Mutations in the X-linked MECP2 gene are the monogenic origin of Rett syndrome (RTT), ...
3. Gulmez Karaca K, Brito DVC, Oliveira AMM. MeCP2: A Critical Regulator of Chromatin in Neurodevelopment and Adult Brain Function. Int J Mol Sci. 2019 Sep 16;20(18):4577. doi: 10.3390/ijms20184577. PMID: 31527487; PMCID: PMC6769791....
3. Gulmez Karaca K, Brito DVC, Oliveira AMM. MeCP2: A Critical Regulator of Chromatin in Neurodevelopment and Adult Brain Function. Int J Mol Sci. 2019 Sep 16;20(18):4577. doi: 10.3390/ijms20184577. PMID: 31527487; PMCID: PMC6769791....
1999年,Amir等[4]在Rett综合征病人中发现了甲基化CpG结合蛋白-2(methyl-CpG-binding protein 2, MECP2)基因功能缺失型突变,定位于Xq28。不到6年,科学家发现MECP2过表达(duplication /triplication)同样可以导致男孩严重的孤独症样表现、智力障碍、反复感染和过早夭折,称为MECP2重复综合征(MECP2 duplication ...
MicroRNAs (miRNAs) are a class of small, noncoding RNAs that function as posttranscriptional regulators of gene expression. Many miRNAs are expressed in th... W Hao,J Tao,PJ Chen,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 244发表:...
3 Bajikar, S. S. et al. MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function.eLife12 (2023). https://doi.org:10.7554/eLife.83806 BioART战略合作伙伴 (*排名不分先后) BioART友情合作伙伴 (*排名不分先后)
The alternative splicing of proteins is critical for normal communication between neurons and may also be necessary for the function of other types of brain cells.根据您的关注的重组人MECP2(甲基化CpG结合蛋白2),重组人Methyl-CpG-binding protein 2,重组甲基化CpG结合蛋白2,rMECP2,重组MECP2,...
The MeCP2 helps regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes. The MeCP2 protein is present in cells throughout the body, although it is particularly abundant in brain cells.In the brain, the MeCP2 protein likely...
3. Gulmez Karaca K, Brito DVC, Oliveira AMM. MeCP2: A Critical Regulator of Chromatin in Neurodevelopment and Adult Brain Function. Int J Mol Sci. 2019 Sep 16;20(18):4577. doi: 10.3390/ijms20184577. PMID: 31527487; PMCID: PMC6769791....