POLYMER-SUPPORTED RADIOPHARMACEUTICALSThe effects of atomic oxygen on several classes of polymers were investigated. Particular attention was directed to the determination of erosion or mass loss mechanisms in relation to the physical and chemical structures of polymers. Nineteen polymeric materials were ...
For example, the correlation of process parameters, device performance, and stability; the influence of passivation and post-treatment techniques; the erosion of device structure by moisture and oxygen; the intermediates and final products formed during the degradation processes; the generation mechanism ...
degradationdiffusionerosionArticleIntroduction Drug delivery systems with extended-release profiles are ideal in improving patient compliance with enhanced efficacy. To develop devices capable of a prolonged delivery kinetics, it is crucial to understand the various underlying mechanisms contributing to extended...
Several long-acting injectables have been approved by tailoring the drug molecules at molecular as well as particulate levels, Covalent linking of fatty acyl chain to the molecules to form ester pro-drug, which increases the lipophilicity and enhances partitioning in the fatty tissues has been the ...
Autoimmune disorders are characterized by aberrant T cell and B cell reactivity to the body’s own components, resulting in tissue destruction and organ dysfunction. Autoimmune diseases affect a wide range of people in many parts of the world and have be
and activation of immune system. Advanced plaques undergo rupture or erosion, leading to thrombosis, which blocks arteries and obstructs blood flow, eventually causing a series of life-threatening clinical manifestations, such as acute myocardial infarction, heart failure, and stroke [2]. Therefore, ...
ablation temperatures, phase evolution during ablation, and ablation morphologies in the different ablation regions consisted of oxidation of the carbon fibre and ceramic matrix, emission of various gases, the flow of high-viscosity SiO2, and denudation of Cf under the erosion of the ablation flame....
Water treatment is of paramount importance to ensure the availability of clean and safe drinking water. In recent years, clay-based materials have gained s
The key to improving the host-implant interaction and consequently the regenerative results may lie in a better ‘use’ of tissue macrophages. First, these cells always and abundantly present at the host-implant interface (after the brief action of neutrophils) and are the primary cell population...
The chemical structure of the polymer chain directly affects the drug release profile through water uptake in the early stages or degradation and erosion in later stages. It also affects the release profile indirectly, through the polymer's 3D porous structure. However, this effect is minor. The...