Mechanisms of lymphatic metastasis in human colorectal adenocarcinoma. J Pathol 2009; 217: 608-19.Royston D, Jackson DG. Mechanisms of lymphatic metastasis in human colorectal adenocarcinoma. J Pathol 2009;217:608-19.Royston D, Jackson DG. Mechanisms of lymphatic metastasis in human colorectal ...
Furthermore, gene set enrichment analysis (GSEA) and pathway analysis demonstrated that MEOX1 was involved in various LNM-related biological activities, such as lymphangiogenesis, lymphatic vessel formation during metastasis, epithelial-mesenchymal transition (EMT), G2/M checkpoint, degradation of ...
G. Mechanisms of lymphatic metastasis in human colorectal adenocarcinoma. J. Pathol. 217, 608–619 (2009). CAS PubMed Google Scholar Mlecnik, B. et al. The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis. Sci. Transl Med. 8, 327ra26 ...
Lymphatic metastasis is a continuous and complicated process. The detailed mechanisms of lymphatic metastasis are still not very clear, despite considerable research efforts in recent years. Previously, it was commonly accepted that there were no lymphatic vessels in the primary tumor. However, recent ...
Detmar Mechanisms of lymphatic metastasis J. Clin. Investig. Am. Soc. Clin. Investig., 124 (3) (2014 3), pp. 922-928, 10.1172/JCI71606 View in ScopusGoogle Scholar [50] I.S. Brown Pathology of perineural spread J. Neurol. Surg. B Skull Base (2016), pp. 124-130 View in Scopus...
2 Targeting metastasis seeding and colonization remains an unresolved challenge despite extensive research available.3 Continued study of the biological mechanisms underlying tumor cell (TC) dissemination and outgrowth is essential.4 TCs migrate throughout the lymphatic and blood circulations during the ...
[73]. In colon cancer, miR-192 levels in serum and tissue samples from colon cancer patients have been linked to poor differentiation, lymphatic metastasis, vascular invasion, and advanced TNM stages, further underscoring the prognostic value of miR-192 [27,31,42,43]. Reduced miR-192 ...
proteolytic enzyme secretion, expression and de-expression of adhesion molecules, the development of new blood and lymphatic vessels in and around tumors, and immune reactivity [6]. Early pharmacologic studies, using drugs that target biochemical stages in metastasis, show some promise but the field ...
multistep process that involves a number of distinct changes in cell phenotype. Thus, the invasion-metastasis cascade has been proposed to be constituted of the following discrete steps: local invasiveness, intravasation (invasion into blood and lymphatic vessels), transport through the circulation, ...
Metastasis is a process in which tumor cells spread from the primary sites to other parts of the body via lymphatic and/or blood circulation [5]. This phenomenon entails a sophisticated sequence of cellular and biological events that can be summarized as follows: (1) In the primary tumor, ca...