Mechanisms of cytochrome P450 reactions. Acta Chim Slov. 2008;55(1):7.Mechanisms of cytochrome P450 reactions. Guengerich,F.P,Isin,E.M. Acta Chim.Slov . 2008Guengerich, F. P.; Isin, E. M. Mechanisms of Cytochrome P450 Reactions. Acta Chim Slov 2008, 55, 7-19....
This article reviewed the mechanistic explorations on CYP450catalyzed reactions, especially the recent investigations on the mechanism of ethanol oxidation catalyzed by CYP450, as well as those in CYP450 drug metabolism. 展开 关键词: Cytochrome P450 Enzyme catalyst Mechanistic studies ...
facilitated by distinct enzymatic reactions within barrier organs such as the intestines, lungs, and skin, largely influenced by resident microbiota [74,75,76,77]. The gut microbiota, which outnumbers human cells significantly, profoundly influences Trp metabolism [78,79,80,81]. The interaction bet...
Cell death can be executed through different subroutines. Since the description of ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been mounting interest in the process and function of ferroptosis. Ferroptosis can occur through two major pathways, the extrinsic ...
Inhibition of thymidylate synthase by fluoro-dUMP. Imidazole antimycotic drugs are examples of such group that inhibit several subtypes of cytochrome P450 [Sharma, 1990]. The mechanisms of toxicities and antidotes of irreversible inhibitors are of medical pathological importance. Because of the ...
Fig. 1: Overview of ROS generation and elimination. Reactive oxygen species (ROS) are labile oxygen-containing molecules primarily generated by the mitochondrial electron transport chain (ETC), peroxisomes, NADPH oxidase (NOX), lipoxygenase (ALOX), cyclooxygenases (COXs), and cytochrome P450s (CYPs...
Human aromatase enzyme is the product of the CYP19A1 gene on chromosome 15 and belongs to the family named cytochrome P450. In vertebrates it catalyzes the synthesis of estrogen via aromatization of androgen precursors namely testosterone and androstenedione. Ovaries are the primary site of estrogen...
In addition, the I/R injury resulted in the release of cytochrome C via mitochondrial permeability transition pore (mPTP) channel, which is made of protein complexes. Monoamine oxidase is located in the mitochondrial membrane, and contains two types, MAO-A and MAO-B, with MAO-A being the ...
The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically... Critical elements from studies that have led to our current understanding of the factors that cause the observed primary deuterium isotope effect...
The P450-based insecticide metabolic resistance is typically mediated by hydroxylation, dealkylation and other oxidative reactions, which is often involved in the increased expression of one or more P450 genes (Lu et al., 2021). CAP resistance in lab-selected and field strains of Plutella xylo...