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Tuberculous pericarditis rapidly progressing within a rather short period of time, a relatively rare complication of diffuse tuberculosis, might have been an immediate cause of death. This would aptly coincide with a startling opinion that in an autopsy picture the composer's heart had been more ...
Hypertension, characterised by a constant high blood pressure, is the primary risk factor for multiple cardiovascular events and a major cause of death in adults. Excitingly, innovations in high-throughput technologies have enabled the global exploration of the whole genome (genomics), revealing dysregu...
which might be independent of its protective role against AD [24,25], it is not entirely benign.APOE*ε2is associated with an increased risk of cerebral amyloid angiopathy (CAA) which often co-exists with AD pathology and is a major cause of hemorrhagic stroke [26,27].APOE*ε2is also a...
Ovarian cancer is the leading cause of gynecological cancer-related death. Drug resistance is the bottleneck in ovarian cancer treatment. The increasing use of novel drugs in clinical practice poses challenges for the treatment of drug-resistant ovarian cancer. Continuing to classify drug resistance acc...
Recent research has focused on the reduction of tau pathology for AD treatment, owing to an increased understanding of the molecular mechanisms involved in the formation of neurofibrillary tangles (NFT) which block nerve synapses and cause neuronal cell death. The formation of neurofibrillary tangles ...
Vascular calcification, especially medial artery calcification, is associated with cardiovascular death in patients with diabetes mellitus and chronic kidney disease (CKD). To determine the underlying mechanism of vascular calcification, we have demonstrated in our previous report that advanced glycation end...
However, as the pathogen continues to proliferate and cause the death of the host cell, it enters the necrotrophic phase. At this time, the pathogen has completed colonization, and the host plants activate JA/ET-mediated ISR to enhance the expression of defense genes to strengthen defense ...
(AMPs) and polymyxin, thus promoting the survival of bacteria. (c) The CPS located on the surface of bacteria adhere to polymyxin, which promotes the cleavage of polymyxin to the bacterial cell wall and finally promotes the death of bacteria. Positive regulation is indicated by red arrow, and...
Brain ischemia is one of the most common causes of death and the leading cause of adult disability in the world. Brain ischemic preconditioning (BIP) refers to a transient, sublethal ischemia which results in tolerance to later, otherwise lethal, cerebral ischemia. Many attempts have been made ...