Objective Cross-breeding a female mouse transgenic for human angiotensinogen (hAGT) with a male mouse transgenic for human renin (hREN) has been described as a model of preeclampsia with hypertension (HTN), proteinuria, and seizures (Science 1996). Our objective was to investigate mechanism of ...
Hypertension and proteinuria are common side effects of this treatment [1,3-7]. These features are also characteristic for preeclampsia. Accumulating evidence indicates that an imbalance between proangiogenic and antiangiogenic factors is involved in the clinical features of preeclampsia.Stephanie Lankhorst...
"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia," J. Clin. Investig., vol. 111 (5) (2003), pp. 649-658 View in ScopusGoogle Scholar [43] X. Huang, Q.T. Le, A.J. Giaccia "MiR-210...
Natural flavonoid quercetin enhances the anti-inflammatory effects of aspirin in a preeclampsia-like rat model induced by lipopolysaccharide. BACKGROUND\nPreeclampsia is a disorder of hypertension and proteinuria accompanied by abnormal inflammatory responses. Both aspirin and quercetin possess a... D Chen...
preeclampsiasoluble fm-like tyrosine kinase-1A disturbed balance between angiogenic and antiangiogenic growth factors is a highly accepted mechanism in the pathogenesis of pregnancy-induced hypertension and proteinuria, which is clinically known as preeclampsia (PE). We investigated the effect of magnesium...
INTRODUCTION: Circulating factors have been proposed to play a major role in the pathophysiology of endothelial dysfunction observed in preeclampsia (PE), defined as new-onset hypertension with proteinuria after 20 weeks of gestation. We hypothesized that circulating factors in PE plasma lead to ...
Preeclampsia is a human pregnancy-specific disorder that is diagnosed by the new appearance of hypertension and proteinuria after 20 weeks' gestation. It is a leading cause of perinatal morbidity and mortality, and the only intervention that effectively reverses the syndrome is delivery. Oxidative ...
RESULTS :Prophylactic administration of low and high doses of tadalafil improved l-NAME induced hypertension, proteinuria, maternal weight loss during pregnancy, fetal growth restriction and flow-mediated dilatation, balanced endothelial-relative factors, and alleviated inflammation activation in placenta and...
Preeclampsia is a heritable pregnancy disorder that presents new onset hypertension and proteinuria. We have previously reported genetic linkage to preeclampsia on chromosomes 2q, 5q and 13q in an Australian/New Zealand (Aust/NZ) familial cohort. This current study centered on identifying the ...
Objective Studies show that proteinuria in preeclampsia is associated with podocyturia. Epidemiological studies have shown that preeclampsia is associated with future proteinuria and renal disease. Little is known about the resolution of podocyturia from time of delivery to 6wks postpartum. We ...