Mechanism of opioid addiction and its intervention therapy: Focusing on the reward circuitry and mu‐opioid receptordoi:10.1002/mco2.148Zhang, Jia‐JiaSong, Chang‐GengDai, Ji‐MinLi, LingYang, Xiang‐MinChen, Zhi‐NanMedComm
The scientists, who published their discovery on Oct. 22 inCell Reports, used an advanced imaging technique to visualize brain cell activity during exposure to an opioid, in a part of the brain known to be centrally important for addiction. They found that key brain-cell changes that occur wit...
breaking the pathologic balance caused by drug taking,reconstructing relatively healthy circuits related to addiction at new level by compensating of brain function and appropriate mental-behavior rehabilitative therapy after operation,then attain to a purpose of reducing drug psychological dependence and ...
Delta-type opioid receptor Agonist + 1 more target Identification Summary Methadone is an opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction. Brand Names Diskets, Dol...
years, there's a consistent portion of the population that continues to smoke, and a continued need for research into tobacco addiction. This study helps us understand a bit more about the brain circuitry involved in this dependence, which is also relevant to opioid and cannabinoid addiction. ...
Mechanism of Action Kappa-type opioid receptor Antagonist Mu-type opioid receptor Partial agonist Identification Summary Buprenorphine is a partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction. Br...
The κ-opioid receptor (KOR) has emerged as an attractive drug target for pain management without addiction, and biased signaling through particular pathways of KOR may be key to maintaining this benefit while minimizing side-effect liabilities. As for m
Mechanism of action refers to how the body works on a cellular level to produce the intended effects of a drug. In the case of Tramadol, the intended effect is pain relief. The mechanism of action for Tramadol is not exactly known. But it is known to act on the mu opioid receptors to...
Similarly, after the opioid receptor is stimulated, the level of dopamine in NSSI patients increases, and one may obtain a sense of pleasure from self-harming behavior. With regard to comorbidities, NSSI had some partially overlapping mechanisms compared with suicide, addiction, eating disorders, ...
Although much attention has focused on the VTA-NAc pathway, many other brain sites that are not yet extensively studied are also likely to contrib- ute to nicotine reward and addiction. Chronic nicotine-induced neuroadaptations Most smokers report that the first cigarette of the day produces the ...