Many of these proteins act as both inhibitors and activators of exocytosis, which is critical for the exquisite regulation of neurotransmitter release. It is still unclear how the actions of these various proteins and multiple other components that control release are integrated and, in particular, ...
Mechanism of neurotransmitter release inhibition by tetanus and botulinum neurotoxins: G. Schiavo,1O. Rossetto,1B. Poulain,2F. Benfenati,3C. C. Shone,4B. R. DasGupta5 and C. Montecucco1 (1 Centro CNR Biomembrane and Dip. Scienze Biomediche; 2 CNRS Neurobiologie Moleculaire, Gif-sur-...
Lack of a docking mechanism for neurotransmitter release in the aganglionic segment of bowel in patients with Hirschsprung\"s disease: Y. Kakita, K. Ohshiro, P. Puri, et al. Pediatr Surg Int 13:581–583, (October), 1998 来自 onAcademic 喜欢 0 阅读量: 22 ...
knockdown experiments were performed using siRNA againstnur77mRNA. First, it was confirmed that knockdown ofnur77mRNA inhibited neurite outgrowth after treatment with forskolin. Neurite length in cells treated with siRNA againstnur77mRNA in the presence of forskolin was significantly lower than ...
Neuronal communication occurs via an electrochemical gradient; the action potential travels through the neuron cell body and generatesneurotransmitter releaseto the synaptic cleft[29]. It has been seen that the most important brain regions in cognition, such as the prefrontal cortex and the ...
This powerful combined analytical approach establishes the existence of an unsuspected strong link between vesicle structure and exocytotic dynamics which can be used to explain the mechanism of regulation of synaptic plasticity by Zn 2+ through modulation of neurotransmitter release....
Mitochondrial calcium is crucial for the production of ATP [103]. However, calcium overload caused by anesthesia and surgery can lead to ATP imbalance, mitochondrial dysfunction, release of inflammatory factors, neuronal cell apoptosis, abnormal neurotransmitter release, and synaptic transmission disorders...
Now Harvard Medical School researchers have discovered a gene that provides that boost by increasingneurotransmitter releasein a phenomenon known as synaptic facilitation. And they did so by turning on a light or two. The gene is synaptotagmin 7 (syt7 for short), a calcium sensor that dynamically...
et al. Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron 65, 66–79 (2010). Article CAS PubMed PubMed Central Google Scholar Burré, J., Sharma, M. & Südhof, T.C. α-Synuclein assembles into higher-...
The results suggest that a major component of secretagogue-induced reduction in fluid transport in vitro is due to mechanical changes in the submucosa, probably induced by modulation of neurotransmitter release within the tissue.doi:10.1113/jphysiol.1988.sp017295...