The anticoagulant drug warfarin and the lipid lowering statin drugs are commonly co-administered to patients with cardiovascular disease. Clinically significant drug-drug interactions (DDIs) between these drugs have been recognized for many years, but the biochemical mechanisms causing these interactions ...
Ciraparantag, an anticoagulant reversal agent, is a small molecule specifically designed to bind non-covalently by charge-charge interaction to unfractionated heparin (UFH) and low molecular weight heparin (LMWH). It shows similar binding characteristics to the direct oral anticoagulants (DOAC). Dynami...
All Drugs DrugInteraction 1,2-Benzodiazepine Minocycline may increase the central nervous system depressant (CNS depressant) activities of 1,2-Benzodiazepine. Acamprosate The excretion of Acamprosate can be decreased when combined with Minocycline. Acenocoumarol Minocycline may increase the anticoagulant act...
Psoralen agent used to enhance ultra violet light therapy of psoriasis. Contraindications : Hypersensitivity, anticoagulant therapy, actinic damage, skin cancer, hepatic insufficiency, porphyrias, acute lupus erythematosus, polymorphic light eruptions or other risk factors for skin cancer such as immunosuppre...
Curcuma is also a commonly applied TCM with anti-inflammatory, anticoagulant, analgesic, antitumor, hypolipidemic, and other pharmacological effects. Clinically, the antitumor effect of curcuma is particularly prominent. However, the precise mechanism underlying its anticancer activity against OS remains ...
Mechanism of Action Prothrombin Inhibitor Identification Summary Lepirudin is a protein-based direct thrombin inhibitor used as an anticoagulant in patients with heparin-induced thrombocytopenia. Generic Name Lepirudin DrugBank Accession Number DB00001 Background Lepirudin is a recombinant hirudin formed by 65...
Topiramate: May decrease the effect of the oral contraceptive, Mestranol. Tretinoin Oral: Tretinoin may decrease the effect of oral contraceptive, Mestranol. Warfarin: Mestranol may alter the anticoagulant effect ofwarfarin. Hepatic Dose : Contraindicated in liver disease....
Overall, the effect of ILT on AA remains pathological rather than protective.127,133Therefore, anticoagulant treatment could reduce ILT assessment and demonstration, but whether it can reduce the possibility of AAA rupture requires further study.134Because of the property of ILT to promote AA rupture...
All Drugs DrugInteraction Abciximab Ginkgo biloba may increase the anticoagulant activities of Abciximab. Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Ginkgo biloba. Abrocitinib The metabolism of Abrocitinib can be decreased when combined with Ginkgo biloba. Acalabrutinib...
Dicoumarol Tetracycline may increase the anticoagulant activities of Dicoumarol. Dicyclomine Tetracycline may decrease the excretion rate of Dicyclomine which could result in a higher serum level. Didanosine Didanosine can cause a decrease in the absorption of Tetracycline resulting in a reduced serum concen...