Consistent with such a mechanism for putative alcohol-associated testicular toxicity are the observed reductions in the testicular content of polyenoic fatty acids and glutathione (GSH) content of the testes of alcohol-fed animlas as compared to isocalorically fed controls. The later finding ...
further strategies to engineer tolerance. Finally, the possibility to use furfural as a model inhibitor of dilute acid pretreated lignocellulosic hydrolysate is discussed. The furfural tolerant strains will harbor an efficient lignocellulosic carbon to pyruvate conversion mechanism in presence of stressors i...
Drug addiction remains a prevalent and fatal disease worldwide that carries significant social and economic impacts. Recent reports suggest illicit pregabalin (Lyrica) use may be increasing among youth, however the addictive potential of pregabalin has n
A. A case study of the mechanism of alcohol-mediated Morita Baylis–Hillman reactions. The importance of experimental observations. J. Am. Chem. Soc. 137, 3811–3826 (2015). Article CAS PubMed PubMed Central Google Scholar Jorner, K., Brinck, T., Norrby, P.-O. & Buttar, D. ...
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is the third leading cause of cancer-related death in human. Alcohol is a known risk factor for HCC. However it is still unclear whether and how alcohol enhances the progressio
Therefore, the ability of PLGAs to minimize the toxicity in the course of the drug release has extended their applications in DDSs [49,50]. In addition, other kinds of degradable and nondegradable synthetic polymers such as polyvinyl alcohol (PVA) [51,52], ethylene vinyl acetate...
Lithium – metronidazole increases the risk of lithium toxicity Cautions/Contraindications Alcohol must not be drunk while on metronidazole and for ~48 hours after the end of the course. Metronidazole interferes withalcohol metabolismand gives severe side effects as a result. ...
Abstract The toxicity towards viruses of silver nanoparticles (AgNPs) has been reported to be dependent on several factors such as particle concentration, size, and shape. Although these factors may indeed contribute to the toxicity of AgNPs, the results presented in this work demonstrate that surfac...
Thus, EcFrmR likely binds Zn(II) via three amino acid side-chains leaving the fourth co-ordination position free, possibly to participate in binding formaldehyde, by analogy to substrate coordination in Zn-dependent alcohol dehydrogenases29. The ability of FrmR proteins to bind Zn(II) raises the...
Subst Alcohol Actions Misuse 3: 259–266. Cooper SJ, Rusk IN, Barber DJ (1989). Sucrose sham-feeding in the rat after administration of the selective dopamine D2 receptor agonist N-0437, d-amphetamine or cocaine. Pharmacol Biochem Behav 32: 447–452. Cooper SJ, van der Hoek GA (1993)...