Action potential mechanism of mammalian cortical neurons in cell culture. Brain Res - Dichter, Lisak, et al. - 1983 () Citation Context ...801 did not limit SV replication in vivo (J. L. Nargi-Aizenman, unpublished results). SV-induced neuronal death is not affected by treatment with ...
Unique features of action potential initiation in cortical neurons. Neurons process and encode information by generating sequences of action potentials. For all spiking neurons, the encoding of single-neuron computations in... B Naundorf,F Wolf,M Volgushev - 《Nature》 被引量: 472发表: 2006年 ...
In the absence of insulin, the glucose-lowering effects of leptin are probably also mediated by LEPR-expressing neurons within the brain, but the biochemical identity of these neurons is still unknown. Once identified, this brain-controlled pathway could be exploited to improve hyperglycaemia in pati...
Consequently, we compared TdP incidence and TDR between male and female rabbit hearts in order to investigate the mechanism of sex difference in TdP risk in rabbits in vitro.Methods By means of monophasic action potential recording techniques, the monophasic action potential of the epicardium, mid...
Capsaicin, a member of the vanilloid family, is known for its ability to elicit burning and painful sensations through its interaction with sensory neurons. This chemical effect is facilitated by its binding to a specific receptor, the vanilloid receptor subtype 1 (VR1), which was ...
Notably, our findings were also observed in Anle138b-treated unseeded neurons, meaning that the inferred processes are independent of tau pathology and thus represent the direct action of the compound in the cellular system. Through structure-based ligand-target prediction, we predicted the ...
Neuronal excitability is one of the most important characteristics of the nervous system, which mainly describes the ability or activity of the generation of an action potential from the steady state [9–13]. Three types of excitability have been studied in the biological experiments and theoretical...
The activity of neurons as computational elements of the brain depends strongly on their spiking activity history, leading to dynamics with a long-term memory effect1,2,3,4. This type of neuronal plasticity differs from current approaches in modern machine learning (ML), such as the stochastic ...
3.1Mechanisms of neurotoxicity Neurotoxicityis related to damage, dysfunction, andneurodegenerationof the neurons in theCentral Nervous System(CNS) or the peripheralnervous system(PNS)[66]. The functionality of the CNS depends on the interaction between neurons and glial cells (astrocytes,olig...
Therefore, PSD-95 inhibitors are believed to provide a safer mechanism of action than NMDA receptor antagonists. However, PSD-95 has many endogenous interaction partners and plays a key role in organizing protein networks and receptor complexes in neurons. Prolonged treatment with PSD-95 inhibitors,...