The oral anticoagulants, derivatives of 4-hydroxycoumarin and indan-1,3-dione, used as therapeutic agents in thromboembolic disease, are antagonists to vitamin K preventing the catalytic use of vitamin K in the
Mechanism of action Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular...
Since the discovery of dicoumarol in 1940, the vitamin K antagonists, primarily warfarin, have been the only oral anticoagulants available. In 2010, the first of a new class of oral anticoagulants was introduced and approved by the US Food and Drug Administration: an oral direct thrombin or fac...
Mechanism of Action Integrase (Human immunodeficiency virus 1) Inhibitor Identification Summary Dolutegravir is an antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents. Brand Names Dovato, Juluca, Tivicay, Triumeq Generic Name Dolutegravir DrugBank Access...
Chen G, Ensor CR, Bohner BA (1954) A facilitative action of reserpin on the central nervous system. Proc Soc exp Biol N Y 86: 507–510 Article CAS Google Scholar Costa E, Guidotti A, Mao CC, Suria A (1975) New concepts on the mechanism of action of benzodiazepines. Life Sci 17:...
Under the action of PARP inhibitors, the content of dsDNA in the cytoplasmic is increased, which activates the cGAS/STING pathway and leads to the generation of type 1 interferon (IFN) reaction, which on the one hand, enhances the relevant chemokines and leads to the accumulation of T cells...
Huangqi Guizhi Wuwu decoction (HQGZWWD) has been used to treat and prevent deep vein thrombosis (DVT) in China. However, its potential mechanisms of action remain unclear. This study aimed to utilize network pharmacology and molecular docking technology
the intestinal microenvironment becomes extremely complicated, and many different types of cells release cytokines, such as interleukin (IL) and TNF, which can trigger inflammatory response via the action of complicated cellular subnets and accelerate, postpone, or even reverse the process of intestinal...
Flavones were shown to inhibit lipid peroxidation; inhibit the uptake of serotonin, dopamine, and norepinephrine; and inhibit platelet aggregation.6 Terpene lactones may also act as potent antagonists of the platelet-activating factor and may possess anti-ischemic and fibrinolytic effects.2 They were ...
Mechanism of Action RAC-beta serine/threonine-protein kinase Inhibitor RAC-gamma serine/threonine-protein kinase Inhibitor Identification Summary Capivasertib is a serine/threonine kinase inhibitor used to treat hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer Brand Name...