(FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric ...
Table 1 Primer sequence of qPCR 表1 qPCR引物序列 PrimerSequence Bcl2F:TGGAGAGCGTCAACAGGGAGATG R:GGTGTGCAGATGCCGGTTCAG Caspase-3F:ACGAACGGACCTGTGGACCTG R:AAGAGTTTCGGCTTTCCAGTCAGAC ADAMTS4F:GCTTCGCTGAGTAGATTCGTGGAG R:TTGACAGGGTTTCGGATGCTTGG ...
Vial HJ, Thuet MJ, Ancelin ML, Philippot JR and Chavis C, Phospholipid metabolism as a new target for malaria chemotherapy: mechanism of action of D-2- Amino-1-Butanol. Biochem Pharmacol33: 2761-2770, 1984.Vial HJ,Thuet MJ, Ancelin ML,et al. Phospholipid metabolism as a new target ...
www.nature.com/scientificreports OPEN Network pharmacological prediction of the mechanism of action of Shen‑Zhu‑Lian‑Bai Decoction in the treatment of ulcerative colitis Li Zhu 1,2* & Jinghua Liang 1* The incidence of ulcerative colitis (UC) is on the rise ...
Structure of TccC3 HVR To understand the processing and function of a Tc toxin HVR as well as its mechanism of action, we chose the TccC3 HVR from Photorhabdus luminescens (hereafter TcHVR) for our studies. Even before the holotoxin consisting of TcA, TcB and TcC is assembled, the TcHVR...
Additionally, it causes extensive metabolic alterations in cancer cells, affecting mitochondrial function and reducing the concentration of specific metabolites involved in the TCA cycle. The transition from quiescence to senescence, known as geroconversion, leads to permanent growth arrest and the ...
Mechanism of action of cholera toxin 来自 Semantic Scholar 喜欢 0 阅读量: 48 作者: RM Tait 摘要: Cholera toxin, obtained as crude culture filtrates of thebacterium Vibrio cholerae, was purified by a combination of ammoniumsulphate fractionation, ion-exchange chromatography on DEAE-cellulose, and...
Medium was removed, and 100 μl/well of 10% cold TCA was added, followed by incubation for 60 min at 4 °C in order to fix the cells. TCA was removed, wells were washed four times with distilled water, and 100 μl/well of 100 μg/ml sulforhodamine B (Sigma) in 10% acetic ...
Cry toxins produced by Bacillus thuringiensis have been recognized as pore-forming toxins whose primary action is to lyse midgut epithelial cells in their target insect. In the case of the Cry1A toxins, a prepore oligomeric intermediate is formed after interaction with cadherin receptor. The Cry1A...
substrates [61]. In a glucose-deprived tumor microenvironment (TME), which is generally seen when nutrients are depleted, high level of lactate is converted into pyruvates (LDH-catalyzed reverse reaction) and then cancer cells can utilize pyruvate for the TCA cycle through the action of pyruvate...