Elucidating the mechanism of action of the clinically-approved taxanes: A comprehensive comparison of local and allosteric effects. Chemical Biology & Drug Design, DOI: 10.1111/cbdd.12595.Churchill CD, Klobukowski M, Tuszynski JA. Elucidating the mechanism of action of the clinically approved taxanes...
The taxanes are a versatile and important class of drugs that target microtubules. Paclitaxel and docetaxel are some of the most widely used cancer chemofh... CH Takimoto,M Beeram - Humana Press 被引量: 2发表: 2008年 MT119, a new planar-structured compound, targets the colchicine site of...
LUAD treatment differs depending on the stage of the disease. Surgical resection or radiotherapy is considered at the early stage [3]. Patients with advanced-stage disease are treated with chemotherapeutic medications such as platinum agents, taxanes, and therapies that target oncogenetic mutation ...
Belzacq-Casagrande, AS., Bachelot, F., De Oliveira, C.et al.Vascular disrupting activity and the mechanism of action of EHT 6706, a novel anticancer tubulin polymerization inhibitor.Invest New Drugs31, 304–319 (2013). https://doi.org/10.1007/s10637-012-9858-y ...
Peripheral sensory and motor neuropathy related to nerve axonal degeneration is a known toxicity of microtubule-inhibiting chemotherapeutic agents, including taxanes, vinca alkaloids, and auristatins (Adcetris [package insert], 2012, Park et al., 2008). Given that maytansines and DM1 share this mech...
Furthermore, they found that kaempferol could also inhibit the absorption of lactic acid in MCF-7 breast cancer cells, leading to cancer cell death [31]. (Fig.1B) The anticancer action of Kaempferol role also can be mediated by ER. Hung et al. reported that kaempferol could induce the ...
The significant anticancer activities of these taxanes make the microtubule stabilizers particularly interesting in cancer therapeutics2. However, the limitations of their intrinsic and acquired drug resistance and dose-limiting toxicities prompt the development of new classes of microtubule-stabilizing drugs3...
[96]. Common chemotherapeutic drugs, including taxanes, platinum agents, vinca alkaloids and erlotinib, activate NFκB and its prosurvival downstream targets, which contribute to chemoresistance [97]. Activation of the NFκB pathway is correlated with platinum resistance and leads to poor prognosis in...
This study supports an in vivo role for immune (particularly NK cell) responses in the mechanism of trastuzumab action in breast cancer. These results suggest that trastuzumab plus taxanes lead to enhanced NK cell activity, which may partially account for the synergistic activity of trastuzumab and...
While TNBC has shown relative sensitivity to anthracyclines and taxanes (Bai et al. 2021), their application is limited by serious side effects and drug resistance. Natural products are known for their favorable therapeutic effects, high safety profile, minimal side effects, and broad potential, ...