Sotalol Atenolol may increase the arrhythmogenic activities of Sotalol. Spirapril Atenolol may increase the hypotensive activities of Spirapril. Spironolactone The risk or severity of hyperkalemia can be increased when Atenolol is combined with Spironolactone. St. John's Wort The metabolism of Atenolol ...
Sotalol Benzydamine may decrease the antihypertensive activities of Sotalol. Sparfloxacin Benzydamine may increase the neuroexcitatory activities of Sparfloxacin. Sparsentan The risk or severity of adverse effects can be increased when Benzydamine is combined with Sparsentan. Spirapril The risk or severity of...
This hypothesis is supported by the results of recent experimental studies involving elucidation of the mechanism of antiarrhythmic-defibrillating effects of sotalol. Enhancement of intercellular communication and myocardial synchronization are thought to play critical role in the mechanism of action of this...
A study of the antiarrhythmic action of certain beta-blocking agents The effects of the beta-blocking agents, MJ-1999 (sotalol) and practolol, against ouabain and digoxin-induced ventricular rhythm disturbances were studied to evaluate the nature of the action which is involved in the ...
The role of D-sotalol on action potential duration (APD) of different layer myocytes, TDR, EAD, R-on-T extrasystole and polymorphous ventricular tachycardia (PMVT) were observed. In arterially perfused rabbit left ventricular wedge preparations, D-sotalol (100 umol centre dot L~(-1)) ...
The role of I> sotalol on action potential duration (APD) of different layer myocytes, TDR, EAD, R-on-T extrasystole and polymorphous ventricular tachycardia (PMVT) were observed. Results In arterially perfused rabbit left ventricular wedge preparations, D-sotalol (100 umol 路 L~(-1) ) ...
Methods Transmembrane action potentials from epicardium and endocardium were recorded simultaneously by using floating glass microelectrode,together with a transmural ECG,in arterially perfused rabbit left ventricular preparations.The role of D-sotalol on action potential duration(APD) of different layer ...
Methods Transmembrane action potentials from epicardium and endocardium were recorded simultaneously by using floating glass microelectrode,together with a transmural ECG,in arterially perfused rabbit left ventricular preparations.The role of D-sotalol on action potential duration(APD) of different layer ...
Absence of antagonist effect in the radioreceptor assay eliminates the potential role of beta 1-blockade in d-sotalol-induced heart rate reduction. This effect is most likely a result of prolongation of the sinus node action potential duration....
After perfusion with d-sotalol, the 90%monophasic action potential duration was prolonged in both male and femlae rabbits. TDR in male and female rabbit hearts increased to (29 卤 2) ms and (61 卤 2) ms, respectively, a difference that is significant. Eight female rabbit hearts had early...