Pyrazinamide (pyrazine-2-carboxamide) is a first-line antituberculous agent critical to the success of short-course chemotherapy of tuberculosis. It is a derivative of nicotinamide, first synethesized in 1952 and subsequently shown to posse
Pyrazinamide is an important sterilizing drug that shortens tuberculosis (TB) therapy. However, the mechanism of action of pyrazinamide is poorly understoo... Z Ying,WM Margaret,S Angelo,... - 《Journal of Antimicrobial Chemotherapy》 被引量: 514发表: 0年 Sequence analysis for detection of firs...
Pyrazinamide Mesalazine may decrease the excretion rate of Pyrazinamide which could result in a higher serum level. Pyridoxine Mesalazine may decrease the excretion rate of Pyridoxine which could result in a higher serum level. Quetiapine The risk or severity of hypertension can be increased when Mesal...
Pyrazinamide Lorazepam may decrease the excretion rate of Pyrazinamide which could result in a higher serum level. Pyridoxine Pyridoxine may decrease the excretion rate of Lorazepam which could result in a higher serum level. Quazepam The risk or severity of CNS depression can be increased when Lora...
Anaerobic incubation conditions enhance pyrazinamide activity against Mycobacterium tuberculosis. J. Med. Microbiol. 53, 769–773 (2004). Article CAS PubMed Google Scholar Zhang, Y., Wade, M. M., Scorpio, A., Zhang, H. & Sun, Z. Mode of action of pyrazinamide: disruption of Mycobacterium...
Although TB is among the oldest known human-affecting diseases, the actual therapeutic regimen involves a combination of outdated antibiotics such as isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin, fluoroquinolones, amikacin, kanamycin, and capreomycin over for at least six months [3]. (...
Pyrazinamide Icosapent may decrease the excretion rate of Pyrazinamide which could result in a higher serum level. Quetiapine The risk or severity of hypertension can be increased when Icosapent is combined with Quetiapine. Quinapril The risk or severity of renal failure, hyperkalemia, and hypertension...
Pyrazinamide Pyrazinamide may decrease the excretion rate of Ampicillin which could result in a higher serum level. Pyridoxine Pyridoxine may decrease the excretion rate of Ampicillin which could result in a higher serum level. Quetiapine Ampicillin may decrease the excretion rate of Quetiapine which cou...
Pyrazinamide Piroxicam may decrease the excretion rate of Pyrazinamide which could result in a higher serum level. Pyridoxine Piroxicam may decrease the excretion rate of Pyridoxine which could result in a higher serum level. Pyrimethamine The metabolism of Piroxicam can be decreased when combined with...
Pyrazinamide Acyclovir may decrease the excretion rate of Pyrazinamide which could result in a higher serum level. Pyridoxine Acyclovir may decrease the excretion rate of Pyridoxine which could result in a higher serum level. Pyrimethamine The excretion of Acyclovir can be decreased when combined with ...