Anthony RM, den Hertog A, Mansjo M, et al. New insights into the mechanism of action of pyrazinamide, implications for suscep tibility testing, and future regimens [J]. Int J Mycobacteriol, 2016, 12(5): $71--2.New insights into the mechanism of action of pyrazinamide,implications for ...
Pyrazinamide (pyrazine-2-carboxamide) is a first-line antituberculous agent critical to the success of short-course chemotherapy of tuberculosis. It is a derivative of nicotinamide, first synethesized in 1952 and subsequently shown to posse
Pyrazinamide Mesalazine may decrease the excretion rate of Pyrazinamide which could result in a higher serum level. Pyridoxine Mesalazine may decrease the excretion rate of Pyridoxine which could result in a higher serum level. Quetiapine The risk or severity of hypertension can be increased when Mesal...
Pyrazinamide Pyrazinamide may decrease the excretion rate of Amikacin which could result in a higher serum level. Pyridoxine Pyridoxine may decrease the excretion rate of Amikacin which could result in a higher serum level. Quetiapine Quetiapine may decrease the excretion rate of Amikacin which could ...
Anaerobic incubation conditions enhance pyrazinamide activity against Mycobacterium tuberculosis. J. Med. Microbiol. 53, 769–773 (2004). Article CAS PubMed Google Scholar Zhang, Y., Wade, M. M., Scorpio, A., Zhang, H. & Sun, Z. Mode of action of pyrazinamide: disruption of Mycobacterium...
Although TB is among the oldest known human-affecting diseases, the actual therapeutic regimen involves a combination of outdated antibiotics such as isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin, fluoroquinolones, amikacin, kanamycin, and capreomycin over for at least six months [3]. (...
Curcumin is an important bioactive component of turmeric and also one of the important natural products, which has been investigated extensively. The precise mode of action of curcumin and its impact on system level protein networks are still not well studied. To identify the curcumin governed regul...
drug actiondrug-resistanceThe World Health Organization recommends the directly observed therapy short-course (DOTS) regimen, a combination of four first-line antibiotics (isoniazid, rifampicin, pyrazinamide and ethambutol), for the treatment of active pulmonary tuberculosis (TB). However, despite the ...
Pyrazinamide Lorazepam may decrease the excretion rate of Pyrazinamide which could result in a higher serum level. Pyridoxine Pyridoxine may decrease the excretion rate of Lorazepam which could result in a higher serum level. Quazepam The risk or severity of CNS depression can be increased when Lora...
Pyrazinamide Icosapent may decrease the excretion rate of Pyrazinamide which could result in a higher serum level. Quetiapine The risk or severity of hypertension can be increased when Icosapent is combined with Quetiapine. Quinapril The risk or severity of renal failure, hyperkalemia, and hypertension...