Mechanism of the action of neuroleptics of the phenothiazine series on electron transport and oxidative phosphorylation in the mitochondriaNo Abstract available for this article.doi:10.1007/BF00778230P. P. ZagoskinE. M. KhvatovaL. D. Luk'yanova...
Mechanism of action Mequitazine binds to the histamine H1 receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine...
Summary Proteolytic activity of the mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1) paracaspase is required for survival of the ... Daniel,Nagel,and,... - 《Cancer Cell》 被引量: 153发表: 2012年 Characterization of phenothiazine-induced apoptosis in neuroblastoma and gliom...
et al. Mechanistic basis of phenothiazine-driven inhibition of Tau aggregation. Angew Chem Int Ed Engl 52, 3511–3515, doi: 10.1002/anie.201208290 (2013). Article CAS PubMed Google Scholar Congdon, E. E. et al. Methylthioninium chloride (methylene blue) induces autophagy and attenuates tau...
Antitumor evaluation of novel phenothiazine derivatives that inhibit migration and tubulin polymerization against gastric cancer MGC-803 cells Nan Liu Zhe Jin Jianjun Jin Investigational New Drugs (2019) An overview of tubulin modulators deposited in protein data bank Haowei Guo Xingcong Li Linlin ...
Amongst the various proposed mechanisms of action, the cell membrane-mediated one is peculiarly tempting due to the distinctive feature of phenothiazine drug family to accumulate in selected body tissues. In this study, we employ long-scale molecular dynamics simulations to investigate the interactions ...
New aspects concerning the mechanism of action of tranquilizers. The influence of some tranquilizers on protein and nucleic acid synthesesIn Escherichia coli B, nucleic acid and protein syntheses were inhibited in the presence of chlorpromazine, promethazine, 2-chlorophenothiazine and librium. The ...
The diffusion of antioxidants, 2:6-di-t-butyl-4-methylphenol (ionol) and phenothiazine in isotactic polypropene and polyformaldehyde was investigated. Measurements were made by means of C14-labelled ionol and S35-labelled phenothiazine, using the thick-layer method.The diffusion coefficients were ...
Type II NADH:quinone oxidoreductase (NDH-2) is central to the respiratory chains of many organisms. It is not present in mammals so may be exploited as an antimicrobial drug target or used as a substitute for dysfunctional respiratory complex I in neurom
(phenothiazine ring, cyan and yellow curves, respectively) and N27 (piperidine ring, blue curve) Supplementary Fig 8 Distribution of the tilt angle between THZ rings plane and the bilayer normal in the POPC membrane containing systems Supplementary Fig 9 Distribution of the tilt angle be...