Mechanism of action Although the mechanism of action of mesalazine is not fully understood, it is believed to possess a topical anti-inflammatory effect on colonic epithelial cells.14 Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways, i.e., prostanoids, and ...
Mesalazine Cimetidine can cause a decrease in the absorption of Mesalazine resulting in a reduced serum concentration and potentially a decrease in efficacy. Mesoridazine The metabolism of Mesoridazine can be decreased when combined with Cimetidine. Mestranol The metabolism of Mestranol can be decreased...
The incidence of ulcerative colitis (UC) is on the rise globally. Shen-Zhu-Lian-Bai decoction (SZLBD) can relieve the clinical symptoms of UC. This study aimed to investigate the underlying molecular mechanism of SZLBD in the treatment of UC. The key tre
www.nature.com/scientificreports OPEN Network pharmacological prediction of the mechanism of action of Shen‑Zhu‑Lian‑Bai Decoction in the treatment of ulcerative colitis Li Zhu 1,2* & Jinghua Liang 1* The incidence of ulcerative colitis (UC) is on the rise ...
Objective:To observe the effect of Liancao-Xieli Capsule on STAT signal pathway and T cell differentiation in mouse model of ulcerative colitis;Methods:Forty BALB/c mice were randomly divided into the control group,model group,mesalazine group and Liancao-Xieli capsule group.Except the control ...
The pathogenesis of UC is associated with hereditary abnormalities, dietary factors, intestinal barrier dysfunction, intestinal flora imbalance and immune dysregulation [6]. Currently, clinical treatment mainly includes sulfasalazine, mesalazine, azathioprine, prednisone, methotrexate, Janus kinase blockers and...
Comparison of antioxidant and anti-inflammatory effects of honey and Spirulina platensis with sulfasalazine and mesalazine on acetic acid-induced ulcerative colitis in rats GMJ, 8 (2019) 2019 2019-06-10;Epub 2019-01-25 (adsbygoogle = window.adsbygoogle).push(google_ad_client: “ca-pub-92261175...
B. Mesalazine. C. Leflunomide. D. Etanercept. Which cephalosporin is combined with the beta-lactamase inhibitor tazobactam due to the risk of multi-drug resistance? a. Ceftaroline b. Ceftolozane c. Cefdinir d. Cefixime What is the function of cytochrome c oxidase? What is the ...
The endoplasmic reticulum (ER) functions as a quality-control organelle for protein homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated degradation, protein chaperons, and autophagy. ER stress is activated when proteostasis is broken with an accumulation of misfold...
Phase II and III clinical trials have shown that the curative effect of FSEC in relieving UC was not inferior to that of mesalazine granules and enteric-coated tablets, but its pharmacological mechanism is unclear. Therefore, the network pharmacology is used to reveal the more comprehensive ...