Mechanism of action General principles and hyaluronic acid receptor binding Hyaluronic acid works by two basic mechanisms: serving as a passive structural molecule or serving as signaling molecule, depending on the molecule size. The physicochemical properties of high molecular weight HA contribute to ...
Ciraparantag is a small, synthetic, water-soluble, cationic molecule that is designed to bind specifically to UFH and LMWHs. DLS was used to study the association of ciraparantag with various DOACs and control molecules in aqueous solution at physiological pH. The data support the hypothesis th...
Cancer and cardiovascular diseases are leading causes of death worldwide. Among them, breast cancer is one of the most common malignancies in women, while atrial fibrillation is one of the most extensively studied arrhythmias, with significant public health implications. As the global population ages ...
Section > Chapter Weitz, J.I.; Young, E.; Johnston, M.; Stafford, A.R.; Fredenburgh, J.C.; Hirsh, J. Circulation 99(5): 682-689 1999 ISSN/ISBN:0009-7322 9950667 10.1161/01.cir.99.5.682 011636909 Article emailed within 0-6 h ...
In contrast, LMWH and ssLMWH demonstrated 2.9- and 5.1-fold lower EC50 values, respectively, in the presence of the limiting TF concentration. These results suggest that inhibition of intrinsic tenase activity contributes to the mechanism of action for LMWH in plasma. The effect of heparins on ...
The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a major threat to global public health. Although COVID-19 primarily affects the respiratory sy