Possible mechanism of action of L-carnitine in permanent regional ischemia in the rat: Sahar Mouhieddine and Jol de Leiris. Laboratoire de Physiologie Cellulaire. UA CNRS 632. Université Scientifique, Technologique et Médicale. Grenoble. France...
Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alpha), L-carnitine, and the therapeutic drugs allopurinol, 6-mercaptopurine (6-MP) and 5-fluorouracil (5-FU) (By similarity). Mediates the transport of PAH, ...
Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alpha), L-carnitine, and the therapeutic drugs allopurinol, 6-mercaptopurine (6-MP) and 5-fluorouracil (5-FU) (By similarity). Mediates the transport of PAH, ...
and suppressed serum homocysteine and S-adenosylhomocysteine concentrations, downregulated cervical muscular carnitine, triglycerides, H2O2, malondialdehyde, interleukin-6 and ACC expression (P < 0.05 for all) and upregulated CPT1 expression and GSH (P < 0.05 for both).The haemorrhagic liposis of cervi...
DeWied D. Effects of peptide hormones on behaviour. In Ganong & Martini (Eds) Frontiers in neuroendocrinology, pp. 97–140, Oxford University Press, London, 1989 Google Scholar Doležal V, Tuček S. Utilization of citrate, acetylcarnitine, acetate, pyruvate and glucose to the synthesis of ...
Abbreviation: PR domain-containing 16 (PRDM16); carnitine palmitoyltransferase 1B (CPT1B); acyl-CoA synthetase long chain family member 1 (ACSL1); patatin like phospholipase domain-containing protein 2 (PNPLA2); lipase E (LIPE). 5.2. TGR5 promotes the browning of white adipose tissue White ...
The low-grade inflammation is pivotal in obesity and its comorbidities; however, the inflammatory proteins are out of target for traditional drug therapy. Omega-3 (ω3) fatty acids can modulate the downstream signaling of Toll-like receptor (TLR) and tum
[136]. miRNAs can target the components of the TGF-β signaling pathway to mediate drug resistance in ovarian cancer. For instance, miR-33a-5p influences the expression of SMAD2/4 by targeting carnitine O-octanoyl transferase (CROT), which induces paclitaxel resistance in ovarian cancer [137]....
In detached CRC cells, under the action of carnitine palmitoyl transferase 1, FAO was greatly activated, thus increasing the ability of cells to metastasize.324 CRC cells implanted in the liver promoted the metabolism of fructose by upregulating enzyme aldolase B (ALDOB), which provided energy for...
May also function as a low-affinity Na(+)-dependent transporter of L-carnitine through the mitochondrial membrane, thereby maintaining intracellular carnitine homeostasis (PubMed:10215651, PubMed:15107849, PubMed:16729965). May contribute to regulate the transport of cationic compounds in testis across...