An enduring finding has been that lipid solubility correlates with anaesthetic potency, indicating a lipophilic site of action. Suitable sites are the cell membrane bilayer and the proteins imbedded in it. All anaesthetics can affect voltage-gated ion channels, but in general these effects occur at...
Most proteins are insensitive to the presence of anaesthetics at concentrations which induce general anaesthesia, while some are inhibited by certain agent... NP Franks,WR Lieb - 《Nature》 被引量: 765发表: 1984年 Amino acid pharmacology of mammalian central neurones grown in tissue culture. 1....
Krasowski MD, Harrison NL: The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations. Br J Pharmacol. 2000 Feb;129(4):731-43. [Article] Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids...
IT is generally accepted that neutral anaesthetics, such as the n-alkanols and n-alkanes, act from a hydrophobic site1. Discussion has tended to focus on the nature of this site and, particularly, whether it is located in a membrane protein or in the interior of a bilayer2,3. If the ...
Furthermore, the binding site for the volatile anesthetic halothane has been shown to overlap with that of alkanols21, and both isoflurane and servoflurane, which belong to the same class of The halogenated intoxicating general anesthetics, and sedating effects poof teexnptioastuerKevtcohhanign...
Fodale V, Santamaria LB, Schifilliti D, Mandal PK (2010) Anaesthetics and postoperative cognitive dysfunction: a pathological mechanism mimicking Alzheimer’s disease. Anaesthesia. 65(4):388–395 ArticleCASPubMedGoogle Scholar Tachibana H, Hiraoka A, Saito K, Naito Y, Chikazawa G, Tamura K,...
Chronic migraine, which is diagnosed when patients present 15 headache attacks or more per month over at least 3 consecutive months, affects about 1–2% of the general population (Lipton, 2011). After migraine has been diagnosed, its pharmacological treatment can either be abortive or prophylactic...
2001. Mechanism of Action of General Anaesthetics- New Information from Molecular Pharmacology. Current Opinion in Pharmacology 1:78-83.Thompson SA,Wafford K.Mechanism of action of general anaesthetics new information from molecular pharmacology. Current Opinion . 2001...
A PROPOSED COMMON MECHANISM OF ACTION FOR GENERAL AND LOCAL ANAESTHETICS IN THE CENTRAL NERVOUS SYSTEM. Br J Pharmacol Chemother. 1963 Aug; 21 :1–9.FRANK, G. B. & SANDERS, H. D. (1963). A proposed common mechanism of action for general and local anaesthetics in the central nervous ...
1. At the molecular level much progress has been made towards elucidating the mechanisms of action of general and dissociative anaesthetics. However, little is known about how these molecular actions may lead to disruption of cognitive function. 2. A promising physiological correlate of cognitive ...