OBJECTIVETo explore the sedative and hypnotic effects of Naoxinshu Oral Solution (NOS) and elucidate its potential mechanisms of action.METHODSMale Institute of Cancer Research (ICR) mice were randomized into six groups of control, eszopiclone, Tianma Capsules, high-dose NOS, medium-dose NOS and l...
The functional roles of the key residues are verified by mutagenesis, kinetic and structural studies. Our structural and functional data together reveal the molecular mechanism of the allosteric regulation of the αγ heterodimer. Isocitrate dehydrogenases (IDHs) are a family of enzymes that catalyze ...
coli to growth on trimethylamine-N-oxide, prompted an investigation of the EcFrmR protein9. This is worthy of investigation because, although the activities of detoxifying enzymes, such as FrmA and FrmB, have been established, the mechanism(s) used by regulatory proteins to perceive and respond...
Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation Annu Rev. Pharm. Toxicol., 49 (2009), pp. 123-150, 10.1146/annurev.pharmtox.011008.145616 View in ScopusGoogle Scholar [18] Y. Zou, Y.N. Wang, H. Ma, et...
药用植物半夏的杀虫活性及毒杀机制分析-insecticidal activity and toxicity mechanism analysis of medicinal plant pinellia ternata.docx,机制,结果表明,半夏乙醇提取物对甜菜夜蛾乙酰胆碱酯酶(AChE)活性表现出先激活后抑制的特征,随着取食时间延长,体内乙酰胆碱酯酶
In the inner retina, another source of ATP is cholinergic amacrine cells (ACs)26,27. In addition, the enzymes required for deactivating extracellular ATP are also found in the synaptic layers of the rat retina19. It is therefore highly possible that ATP may modulate the activity of retinal ...
between a ‘closed’ and an ‘open’ state induced by PT-stimulated GTP hydrolysis. The closed-to-open transition simultaneously promotes the dissociation of SspE from PT-DNA and turns on the nickase activity of CTD. In summary, this study reveals an exquisite molecular mode of action of SspE...
Several E. coli enzymes involved in T7 RNA metabolism are modified during infection. The phosphorylation of RNA degradosome components RNase E and RNA helicase RhlB serves to stabilize the mRNAs synthesized by the T7 RNA polymerase26,27. RNase III also is phosphorylated during T7 infection in ...
(email: asano@pu-toyama.ac.jp) Scientific Reports | 5:13836 | DOI: 10.1038/srep13836 1 www.nature.com/scientificreports/ structures have been determined previously5–13, and these enzymes can be divided into three classes (A, B, and C) based on differences in their structures and active...
b An illustration of the one-pot chemoenzymatic loading of apo-ACP with panetheinamide probe 1c to produce crypto-1c-ACP using the coenzyme A biosynthetic enzymes CoaA, CoaD, and CoaE and a promiscuous phosphopantetheinyl transferase (PPTase) Sfp. Full size image The AcpP–KS interface The ...