Hypomethylating agents, such as azacitidine (AZA) and decitabine (DAC), are antimetabolites with a very unique mechanism of action as epigenetic regulator. After being incorporated into the DNA, these inhibit the enzyme, DNA methyltransferase, resulting in the hypomethylation of DNA, and change ...
Azacitidine Mesalazine may decrease the excretion rate of Azacitidine which could result in a higher serum level. Azathioprine The risk or severity of myelosuppression can be increased when Mesalazine is combined with Azathioprine. Azelaic acid Mesalazine may decrease the excretion rate of Azelaic acid ...
Azacitidine Azacitidine may decrease the excretion rate of Clonazepam which could result in a higher serum level. Azatadine The therapeutic efficacy of Clonazepam can be decreased when used in combination with Azatadine. Azathioprine Azathioprine may decrease the excretion rate of Clonazepam which could ...
Daniel J. DeAngelo, MD, PhD, discusses the mechanism of action of pevonedistat in myelodysplastic syndrome.
%), etoposide (21.4 %), vincristine (21.4 %) and docetaxel (14.3 %), gemcitabine (14.3 %), ifosfamide (14.3 %), azacitidine (7.1 %), decitabine (7.1 %), fluorouracil (7.1 %), irinotecan (7.1 %), eribulin (7.1 %), busulfan (7.1 %), fludarabine (7.1 %), daunorubicin (...
87 However, in a phase II study, CC-486 (oral azacitidine) did not show sufficient clinical activity to support further development as a monotherapy in advanced NPC.88 Some natural compounds also showed efficacy as DNMT1 inhibitors. Previous studies from our group and other labs have reported ...
R. et al. Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J. Clin. Oncol. 24, 3895–3903 (2006). 39. Shaker, S., Bernstein, M., Momparler, L. F. & Momparler, R. L. ...
Azacitidine, an analog of the cytidine pyrimidine nucle- oside, has received approval by the US Food and Drug Administration for the treatment of all subtypes of MDS [43]. Despite marked activity in myeloid malignancy, the use of azacitidine in patients with solid tumors ...
Azacitidine (AZADecitabine (DACHypomethylating agents, such as azacitidine (AZA) and decitabine (DAC), are antimetabolites with a very unique mechanism of action as epigenetic regulator. After being incorporated into the DNA, thesedoi:10.1007/978-981-10-3332-2_19Shinya Sato...
Signal transducer and activator of transcription (STAT) signaling controls the epigenetic tuning of CD4+ T-cell differentiation and polarization, and perturbed STAT signaling networks in CD4+ T cells subvert antitumor immunity in malignancies. Azacitidine (AZA), the mainstay therapy for high-risk ...