antiviral drugsCOVID-19In the past two decades, the world has faced several infectious disease outbreaks. Ebola, Influenza A (H1N1), SARS, MERS, and Zika virus have had a massive global impact in terms of economic disruption, the strain on local and global public health. Most recently, the...
The mechanism-of-action of many electrohilic drugs remains poorly understood. Here, the authors use a redox-targeting approach to elucidate the basis for the innate immune cell toxicity of dimethyl fumarate, showing that it modifies Keap1 to trigger mitochondrial-targeted neutrophil/macrophage apoptosis...
Although the mechanism of antiviral action is not completely clarified, silver nanoparticles can directly act on viruses, and on their first steps of interaction with the host cell, depending on several factors, such as size, shape, functionalization and concentration. This review provides an ...
Editorial: The Mechanisms of Action of Anti-SARS-CoV-2 Drugs The coronavirus disease 2019 (COVID-19) pandemic has brought great uncertainty to global economic development and social stability and posed a great threat... Z Wu,V Brancaleone,J Sultana - 《Frontiers in Pharmacology》 被引量: 0...
Cilastatin is a renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections.
Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by...
The primary focal point of this lesson will be on the subject of the chemistry of medical drugs. Our main topics of discussion will include how they are classified and their mechanism of action. Can't Live Without Them When you hear the term medical drug what's the first thing that comes...
Mechanism of action of non-fostemsavir Enfuvirtide, a synthetic peptide, is also a class of ARVs that inhibits the entry of the virus into host cells. It has several defects that limit its clinical use, including relatively low antiviral activity, requiring high doses, a lower genetic barrier...
Mechanism of Action Gag-Pol polyprotein Modulator Integrase (Human immunodeficiency virus 1) Inhibitor Identification Summary Dolutegravir is an antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents. Brand Names Dovato, Juluca, Tivicay, Triumeq Generic ...
Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs (PubMed:16434549). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in innate ...