Mechanism of Action Sodium/potassium-transporting ATPase subunit alpha-1 Inhibitor Identification Summary Digoxin is a cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation. Brand Names Digox, Lanoxin Generic Name...
Mechanism of action The primary mechanism of action of amikacin is the same as that for all aminoglycosides. It binds to bacterial 30S ribosomal subunits and interferes with mRNA binding and tRNA acceptor sites, interfering with bacterial growth. This leads to disruption of normal protein synthesis ...
The purpose of this investigation was a complex analysis of the influence of ischemia on changes in the activity of the sarcolemmal Na,K-ATPase and electromechanical coupling in the papillary muscle (PM) of the guinea pig under the action of digoxin. The selected model made it possible to ...
There are no adequate, well-controlled, head-to-head clinical trials comparing BRILINTA and thienopyridines in patients with acute ischemic stroke or high-risk CAD without a history of MI or stroke. The central role of platelets in thrombus formation ...
Martinez-Maldonado, M.; Tsaparas, N.; Inagaki, C. and Schwartz, A.: Interactions of digoxin and ethacrynic acid with renal sodium-potassium-activated adenosine triphosphatase. Journal of Pharmacology and Experimental Therapeutics 188: 605–614 (1974). ...
When binding to other drugs and blood proteins was assessed by DLS methodology, ciraparantag demonstrated no binding to FIIa, FXa (Figure 4A-B), or cardiac drugs (diltiazem, digoxin) (Figure 4C-D). Similar data were obtained for other cardiac drugs (propranolol, lidocaine, metoprolol, lisinopr...
For example, when using digoxin as the only “positive” drug, the AUROC of GSEA was 1, similarly, as shown in Fig. 2, GPAR reached AUROC = 0.99, and the top10 predicted drugs included 5 known Na+/K+_ATPase inhibitors. Fig. 2 L1000FWD visualization data shows a trained Na+/K...
sheep. It binds molecules ofdigoxin, making them unavailable for binding at their site of action on cells in the body. The Fab fragment-digoxin complex accumulates in the blood, from which it is excreted by the kidney. Digoxin therapy can be restarted after 3-7 days after correction of ...
circulating DLI as digoxin using liquid chromatography and mass spectrometry.69 Ouabain is another candidate for an EDLF A hydrophilic digitalis, ouabain, has also been considered a potential EDLF.70–72 Hamlyn et al.73 isolated ouabain or its isomer from a very large volume of human serum in...
Digoxin Paliperidone may decrease the excretion rate of Digoxin which could result in a higher serum level. Dihydralazine Paliperidone may decrease the antihypertensive activities of Dihydralazine. Dihydrocodeine The risk or severity of CNS depression can be increased when Paliperidone is combined with Dih...