Mechanism of action of calcium antagonists and their possible interaction with atherogenesisGuanine nucleotide exchange factor (GEF) is a multisubunit protein involved in the initiation of translation. Although numerous models have been proposed for its mechanism of action, none have been definitive. An...
Structural basis for calcium-stimulating pore formation of Vibrioα-hemolysin Vibrioα-hemolysins (αHLs) are toxins crucial for certain bacterial infections. Here the authors reveal that calcium ions boost the activity of a specific toxin, Vibrio campbelliiαHL, and uncover its calcium-dependent ac...
Henry,D Philip - 《Journal of Cardiovascular Pharmacology》 被引量: 97发表: 1991年 Protective action of calcium channel antagonists in atherogenesis and experimental vascular injury. Experimental research using in vitro and in vivo models of vascular injury have delineated several common mechanisms that...
Effect of adrenergic agents on the secretion of gastrointestinal immunoreactive glucagon in depancreatized dogs. To elucidate the mode of action of adrenergic agents on gastric A cells, the effects of infusion of adrenergic agonists and antagonists on the secretion of... Yoshida,Kondo - 《Diabetes...
Regulation of inflammasome signaling. Nat. Immunol. 13, 333–342 (2012). CAS PubMed PubMed Central Google Scholar Murakami, T. et al. Critical role for calcium mobilization in activation of the NLRP3 inflammasome. Proc. Natl. Acad. Sci. USA 109, 11282–11287 (2012). CAS PubMed Pub...
Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res. 2007; 73 (2):137–150.Taylor CP, Angelotti T, Fauman E. Pharmacology and mechanism of action of pregabalin...
Combining the different approaches, we found evidence supporting the hypothesis that the action of Anle138b involves several processes which are key to AD progression, including cholesterol homeostasis and neuroinflammation. On the pathway level, we found significantly enriched pathways related to these ...
All currently used topical fluoride agents deposit soluble fluoride as calcium fluoride on enamel or in lesions. Calcium fluoride serves as a source of fluoride for the formation of fluorapatite. The latter phase is formed when pH drops in plaque, not during topical application. The potential for...
In addition, AMP PFR induces necroptosis by endoplasmic reticulum (ER) stress, and elevated cytoplasmic calcium and mitochondrial ROS levels [171]. Recent studies suggest that the direct coaggregation of amyloidogenic peptide and amyloids is an important antibacterial mechanism of AMP action [172]. ...
Interestingly, interleukin-1β is known to increase the NMDAR-mediated intracellular calcium [45] and activates p53, eventually leading to excitotoxic neurodegeneration [32]. Hence, suppression of p53 activation and interleukin-1β-mediated gene transcription might confer protection against NMDA. In ...