R. (2007). New insights into the mechanism of action of amphetamines. Annu. Rev. Pharmacol. Toxicol. 47, 681-698. doi: 10.1146/annurev.pharmtox.47.120505.105140Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR (2007). New insights into the mechanism of action of amphetamines. ...
The purpose of this chapter is to review the evidence that substituted amphetamines (AMPHs), such as methamphetamine (METH), have neurotoxic potential, discuss critical determinants of AMPH neurotoxicity, and consider possible mechanisms underlying the neurotoxic action of AMPH and some of its ...
Amphetamines Antidepressive Agents Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 Substrates Ethylamines Hallucinogens Membrane Transport Modulators Neurotransmitter Agents Neurotransmitter Uptake Inhibitors Phenethylamines Psychotropic Drugs Serotonergic...
Phenylalanine and derivatives/Alpha amino acid esters/N-acyl-alpha amino acids and derivatives/Beta amino acids and derivatives/Amphetamines and derivatives/Fatty acid esters/Dicarboxylic acids and derivatives/Methyl esters/Amino acids/Propargyl-type 1,3-dipolar organic compounds ...
we provide a brief review of the existing literature on themechanisms of neurotoxicityconsequent to commonly abused drugs (amphetamines, cocaine, opiates, and alcohol). The chapter also discusses identified predisposing factors, potentials for preventive, and therapeutic approaches, as well as...
A long-term retention of this amine in the brain and a high ratio of brain to plasma concentrations (Melega et al., 1992) indicate that methamphetamine is bound in brain tissue. The pharmacology of amphetamines is complex and not fully understood. However, their interaction with dopaminergic ...
To study the metabolic changes caused by exposure of mice to the HTH environment, we investigated the status of plasma metabolites in male Balb/c mice maintained under different conditions. Specifically, three and ten days after initiating the experiment, we performed LC–MS/MS analysis to compare...
3.4. Trace Amine-Associated Receptor 1 (TAAR1) and LSD: The Shooting Guard Psychostimulant and hallucinogenic amphetamines, numerous ergoline derivatives including ergometrine, dihydroergotamine, and LSD, as well as the antiparkinsonian agents bromocriptine and lisuride, display agonistic activity at the...
In North America barbiturates were widely used by youth gangs and deviant subcultures as depressants and attracted notoriety because they were often taken in combination with other substances (e.g., stimulants such as amphetamines). Alcohol greatly intensifies the depressant effect of barbiturates, ...
Studies on the mechanism of action of amphetamines have provided evidence that the central stimulatory action of amphetamine is mediated through newly synthesized catecholamines, predominantly dopamine, whereas the action of p-chloroamphetamine depends on the store of catecholamines. The author has shown ...