MDX-1338isafullyhumanIgG4monoclonalantibodythatspecificallyrecognizeshumanCXCR4.InvitrostudiesdemonstratethatMDX-1338bindstoCXCR4-expressingcellswithlownanomolaraffinity,blocksCXCL12bindingtoCXCR4expressingcellsandinhibitsCXCL12inducedmigrationandcalciumfluxwithlownanomolarEC50values.Whengivenasmonotherapy,MDX-1338exhibits...
In vivo efficacy was determined in multiple AML, NHL, and multiple myeloma xenograft tumors in severe combined immunodeficient mice.Results: BMS-936564/MDX-1338 is a fully human IgG4 monoclonal antibody that specifically recognizes human CXCR4. In vitro studies show that MDX-1338 binds to CXCR4...
The OS cells responded to 0.5 µg/ml MDX1338 with a cell growth decrease up to 30% (SAOS-2) and 40% (U2OS and 143B) of control after 48 h of treatment. Similarly, the response to 30 µg/ml AMD3100 caused a 40% maximum decrease at 48 h for all OS cell lines (...
BMS-936564/MDX-1338: A Fully Human Anti-CXCR4 Antibody Induces Apoptosis and Shows Antitumor Activity in Hematologic Malignancies Sabbatini P , Cohen L , Shelat S , Cardarelli PM et al ( 2012 ) BMS-936564 (MDX1338): a fully human anti-CXCR4 antibody induces apoptosis in an in vitro model...
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中国人民大学在职研究生学位申请流程及时间 中国人民大学在职研究生学位申请时间为6月初,流程分为以下三个步骤: (一)申请进行同等学力人员资格认定并办理《同等学力人员申请硕士