第三阶段,CMP分化为粒细胞和巨噬细胞前体(Granulocyte and macrophage progenitor, GMP)、巨噬细胞和DC细胞前体(Macrophage and DC progenitor,MDP)、肥大细胞前体(Mast cell progenitor,MCP)、巨核细胞和红细胞前体(Megakaryocyte and erythroid progenitor, MEP),同时,CLP分化为DC前体(Common DC progenitor, CDP); 第...
第三阶段,CMP分化为粒细胞和巨噬细胞前体(Granulocyte and macrophage progenitor, GMP)、巨噬细胞和DC细胞前体(Macrophage and DC progenitor,MDP)、肥大细胞前体(Mast cell progenitor,MCP)、巨核细胞和红细胞前体(Megakaryocyte and erythroid progenitor, MEP),同时,CLP分化为...
·自然调节性T细胞(naturalregulatory T cell,nTreg):来源于微环境 ·诱导性调节性T细胞(inducedregulatory T cell,iTreg):来源于胸腺 注意:由于自然调节性T细胞(naturalregulatory T cell,nTreg)存活时间较短,一般我们研究的是诱导性调节性T细胞(inducedregulatory T cell,iTreg),也统称为Treg细胞。 Treg细胞的诱导...
第三阶段,CMP分化为粒细胞和巨噬细胞前体(Granulocyte and macrophage progenitor, GMP)、巨噬细胞和DC细胞前体(Macrophage and DC progenitor,MDP)、肥大细胞前体(Mast cell progenitor,MCP)、巨核细胞和红细胞前体(Megakaryocyte and erythroid progenitor, MEP),同时,CLP分化为DC前体(Common DC progenitor, CDP); 第...
炎症性肠病患者外周血MDSC、Th1、Th17细胞表达及其临床意义前言1前言炎症性肠病(Inflammatoryboweldisease,IBD)是一组原因不明的非特异性肠道炎症性疾病,包括溃疡性结肠炎(Ulcerativecolitis,UC)和克罗恩病(Crohn'sdisease,CD)[1-3]。UC又称非特异性溃疡性结肠炎,是一种原因不明的直肠和结肠的炎症,病变主要限于大...
PSC会产生大量基质元素,可直接接触免疫细胞并与之相互作用,如PSC可通过分泌白细胞介素-6(interleukin-6,IL-6)而激活人外周血单核细胞(peripheral blood mononuclear cell,PBMC)中信号转导及转录激活蛋白3(signal transducer and activator of transcription 3,STAT3)信号通路,从而诱导MDSC的产生。体外研究发现,人胰腺...
Vincenzo Bronte, SvenBrandau, Shu-Hsia Chen., et al.Recommendations formyeloid-derived suppressor cell nomenclature and characterization standards.NatureCommunications2016 Jul 6; 7:12150. 往期内容回顾: 【流式学习】γδT细胞:虽然我很少,但我很重要 ...
1. Talmadge, J.E. and D.I. Gabrilovich, History of myeloid-derived suppressor cells. Nature reviews. Cancer, 2013. 13(10): p. 739-52. 2. Condamine, T., et al., ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis. The Journal of clinical investig...
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CassettaL , Bruderek K , Skrzeczynska-Moncznik J , et al. Differentialexpansion of circulating human MDSC subsets in patients with cancer, infectionand inflammation[J]. Journal for ImmunoTherapy of Cancer, 2020, 8(2). TesiR J . MDSC; the Most Important Cell You Have Never Heard Of. 20...