Since the late 1980s, patient registries have played a pivotal role in the elucidation of rare diseases. For myelodysplastic syndromes (MDS), they revealed the disease actually to be diverse rather than rare. Registry data enabled the definition of various MDS subtypes and prognostic scores tailorin...
We conducted a meta-analysis of the literature to explore the prognostic significance of GATA2 mutations in patients diagnosed with MDS/AML, as previous studies have yielded conflicting findings regarding the impact of GATA2 mutations on patient outcomes. We conducted a comprehensive literature search ...
This manuscript introduces a multi-level decision system (MDS) for monitoring and detecting patient behavior based on sensed information. The information from the devices is matched with historical data to understand the current state of the patient's health. The process of decision making on the ...
Patient’s global assessment of disease activity and patient’s assessment of general health for rheumatoid arthritis activity assessment: are they equivalent? Annals of the rheumatic diseases, 71 (12) (2012), pp. 1942-1949 View PDFView articleCrossrefView in ScopusGoogle Scholar [46] T Uhlig,...
that to see a statistically significant therapeutic effect, more patients may need to be treated. Additionally, patient selection based on factors beyond just the presence of aTP53mutation may be necessary. For instance, the type ofTP53mutation could be a consideration, as discussed previously [98...
SF3B1mutations occurs in rare HSC phenotypic cells, is largely maintained in more committed progenitors MPPs as well as in more differentiated progenitors GMPs and MEPs. Tables show the progenitor cell counts (events detected by the FACS during cell sorting) for each patient sample. The average se...
who presented IMerge results at ASH. “Further, anemia and fatigue remain two of the most burdensome symptoms of lower-risk MDS, and patient-reported outcomes such as improvement in fatigue and maintenance of quality of life and anemia symptoms may inform treatment choices as we aim ...
All analyses were performed by independent statisticians (ML and JH) from the Institute for Medical Information Sciences, Biometry and Epidemiology of the Ludwig-Maximilians University of Munich, Germany. RESULTS Patient disposition and baseline characteristics A total of 353 patients from the lenalidomide...
Im Verlauf von 60 Monaten waren 63,6 % der Patienten zu irgendeinem Zeitpunkt Thrombozytopenie-frei gewesen. 30 % waren zu irgendeinem Zeitpunkt nicht auf Erythrozytenkonzentrattransfusionen angewiesen. Ein klinisch signifikantes Blutungsereignis (WHO Blutungs-Score ≥ 2) trat im Eltrombopag-...
R.S. Patil, “Causal representation of patient illness for electrolyte and acid-based diagnosis,” Technical Report, no. 267, Massachussetts Institute of Technology, Laboratory for Computer Science, Cambridge, MA, 1981. Google Scholar G.W. Rosenwald and C. Liu, “Rule-based system validation ...