In the 40-mg cohort, two patients experienced DLTs of grade 3 nausea and vomiting and grade 3 hyperbilirubinemia. The MTD for PAN was not reached. Although DLTs were rare, two patients (29%) required at least one PAN dose reduction and one patient (14%) required at least one AZA dose ...
(38%), febrile neutropenia with ANC less than 1.0 x 109/L (32%), thrombocytopenia (16%), neutropenia (13%), oral mucositis (13%), nausea (7%), diarrhea (5%), constipation (4%), tumor lysis syndrome (4%), renal failure (3%), colitis (3%), hyperbilirubinemia (2%), and fatigu...
Results: Three patients had dose-limiting toxicities (DLTs), which were rhabdomyolysis (up to gr 4), hyperbilirubinemia (gr 3), and oral herpes (gr 3). All DLTs occurred in the 6 and 7mg cohorts. Adverse events included febrile neutropenia/infections (n = 3), GI (n = 6) and ...