However, selecting eligible patients for transplantation has been a challenging subject over the last decade [20,21]. A recent study of the Japan Marrow Donor Program concluded that regardless of disease risk, patient clinical features such as performance status, age at transplant, and hematopoietic...
Ideally, evidence supporting the beneficial effects of iron chelation in MDS should rest on proof of improved life expectancy and in exceptional cases, reversal of myocardial disease. However, such evidence is presently unavailable. The selection of MDS patients who may benefit from ICT involves a ...
for a previous cancer; the syndromes are most common in elderly people. The March 21, 2014 pathophysiology involves cytog ic changes with or without gene mutations and widespread gene hypermethylation S0140-6736(13)61901-7 at advanced stages. Clinical manifestations result from cytopenias (anaemia,...
In the present work, we analyzed disease- and patient-related predictive factors for the outcome of allogeneic HSCT in a cohort of 519 patients with primary MDS or oligoblastic AML. Methods Patients and study design This study was approved by the institutional Ethics Committee (Comitato di Bioet...
Concomitant disorders are indeed common in this aged population; in particular, infection and the presence of anemia were more frequent in elderly patients. Whereas younger age may be a favorable factor for survival with lenalidomide, the more severe disease characteristics seen in patients aged <65...
3 Several factors have to be considered in the decision process of “how to select MDS patients as suitable candidates for HSCT.” These can be classified into patient-related and disease-related factors. These factors may determine response to treatment modalities, including intensive chemotherapy (...
The heterogeneity of the disease is seen as the culprit for the limited success. Perhaps we were focusing in the wrong direction, making treatment success nearly impossible. In the absolute knowledge that life is never endless, we should shift our focus towards HRQoL as the most important ...