2,11,12,13 These studies confirmed findings from previous analyses in cell lines,4 namely that MLV-based retrovirus vectors had a non-random propensity to integrate within or near gene coding sequences, specifically near transcription start sites, and that genes highly expressed in target cells ...
The median time from initial diagnosis to study entry for patients with MDS, CMML and AML was 1.3 months (range, 0.5–37.9 months), 1.8 months (range, 0.8–3.2 months) and 0.7 months (range, 0.2–2.5 months), respectively. Most patients had an initial ECOG PS of either 0 (41.9%) or...
This was underscored by further PCA analysis, including normal CD34+ cells, in which the projection of the first 3 principal components showed a methylation “gradient,” with normal CD34+ cells on one extreme, de novo AMLs in an intermediate position, and MDS samples in the opposite end (...
The median time from initial diagnosis to study entry for patients with MDS, CMML and AML was 1.3 months (range, 0.5–37.9 months), 1.8 months (range, 0.8–3.2 months) and 0.7 months (range, 0.2–2.5 months), respectively. Most patients had an initial ECOG PS of either 0 (41.9%) or...