Oncology Frontier-Hematology Frontier:At this conference, you reported on the application of a collaborative palliative and oncology care model in patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome ...
A practical approach on the classifications of myeloid neoplasms and acute leukemia: WHO and ICC. J Hematol Oncol. 2024;17(1):56. Published 2024 Jul 29. 对于TP53阳性的MDS,MDS/AML,AML在TP53突变的要求不一样,造成了WHO与ICC对于TP53阳性...
02AML不伴成熟型、伴成熟型和急性粒单核细胞白血病 这3个细胞分化定义的类型标准中,>3%原始细胞MPO阳性(免疫表型方法或细胞化学),在其他官方文献标准中没有免疫表型方法。 说明:以前解读的信息来自发表在2022年6月“Leukemia”杂志上的WHO-HAEM5文献,最后以即将出版的蓝皮书为准。
Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal hematopoietic stem cell disorders with a poor prognosis, especially for elderly patients. Increasing evidence suggests that alterations in the non-hematopoietic microenvironment (bone marrow niche) can contribute to or initiate ...
目前可用的治疗方案在不适合接受密集化疗的急性髓系白血病(AML)患者中只能产生有限的缓解,且患者的生存率较差。Venetoclax(VEN)作为BCL-2的一种选择性小分子抑制剂,与阿扎胞苷(AZA)联合在不适合接受密集化疗的AML患者中具有良好的疗效和可接受的安全性。
考虑到患儿MDS转化为AML,肺部感染严重,三系极度低下,化疗有可能导致感染的进一步加重,且MDS转化的AML化疗效果差,故未予化疗,给予积极抗感染治疗。 先后给予美平、利奈唑胺抗细菌联合伏立康唑、两性霉素B抗真菌治疗后,患者体温未见明显下降且复查CT感染病灶逐渐增大(图1),后请感染影像专家会诊考虑为肺炎型肺结核,给予...
Today, the classification systems for myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) already incorporate cytogenetic and molecular genetic aberrations in an attempt to better reflect disease biology. However, in many MDS/AML patients no genetic aberrations have been identified yet, and...
在今年美国血液学年会（ASH）上，中国医学科学院血液病医院（中国医学科学院血液学研究所）肖志坚教授带领团队聚焦WHO 2022中MDS新版分型标准的研究成功入选，该研究率先验证了新版分型标准在中国人群中的临床价值，已于今年10月正式发表于国际著名期刊Leukemia，为我国MDS的精准诊断和分层治疗提供了重要依据。本期【博医...
骨髓增生异常综合征(myelodysplastic syndromes,MDS)是一组起源于造血干细胞的异质性髓系克隆性疾病,其特点是髓系细胞发育异常,表现为无效造血、难治性血细胞减少,高风险向急性髓系白血病(AML)转化。为进一步提高和规范我国MDS的诊治水平,中华医学会血液学分会结合近年来MDS领域的最新临床研究成果和国内的实际情况,制订...
Getting the Full Picture of Your Myelodysplastic Syndromes and Acute Myeloid Leukemia (MDS & AML) When you are living with MDS & AML, the MDS & AML Manager can help you manage the symptoms that affect you every day. Studies show that people with chronic diseases can positively affect their ...