Results revealed that many dogs possess the MDR1 gene mutation, with many possessing at least one copy of the mutation. The study discovers the mutation in two breeds and further proves the presence of the mutation in the German Shepherd dog. Furthermore, a large percentage...
As more than 10 dog breeds are predisposed to this mutation, reliable genotyping methods are necessary to identify affected dogs before drug treatment. This study provides a new allelic discrimination method that detects the MDR1 mutation with high specificity and reliability and is useful for ...
subchronic neurotoxicity seen in dogs of non-collie breeds following macrocyclic lactone treatment for generalized demodicosis Altered expression or function of P-gp, as seen in dogs of the collie lineage homozygous for the nt228(del4) mutation of the ABCB1 gene (ABCB1-1螖), can result in ...
The research focuses on the MDR-1 gene mutation, predominantly found in Collies and other related breeds, which affects the functionality of P-glycoprotein, a crucial component of the blood-brain barrier in dogs. This mutation results in heightened sensitivity to certain drugs, ...
Summary A deletion mutation in the canine multidrug resistance gene, MDR1, is associated with drug sensitivity. This was shown for several purebred dog breeds from the Collie lineage such as the Collie (rough‐coated and smooth‐coated), the Australian Shepherd and the Old English sheepdog. To ...
In certain dog breeds a 4-bp deletion mutation of P-glycoprotein encoding ABCB1 (MDR1) gene is frequently occurring. In result of the shift in the reading frame non-functional protein forms which leads to neurological toxicity in the affected individuals after exposure to commonly used ...
A 4-bp deletion mutation associated with multiple drug sensitivity exists in the canine multidrug resistance ( MDR1) gene. This mutation has been detected in more than 10 purebred dog breeds as well as in mixed breed dogs. To evaluate the breed distribution of this mutation in Germany, 7378 ...
A 4-bp deletion mutation exists in the MDR1 gene of many dog breeds such as the Collie and the Australian Shepherd, which results in the expression of a non-functional P-glycoprotein and is associated with multiple drug sensitivity. Accordingly, dogs with homozygous MDR1 mutation are in ...
As more than 10 dog breeds are predisposed to this mutation, reliable genotyping methods are necessary to identify affected dogs before drug treatment. This study provides a new allelic discrimination method that detects the MDR1 mutation with high specificity and reliability and is useful for ...
The genotyping survey demonstrated that the carrier and mutant allele frequencies were 0.49% and 0.25%, respectively, suggesting that the mutant allele frequency in Border Collies is markedly low compared to that in the susceptible dog breeds such as rough and smooth Collies.Keijiro...